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This volume offers the most comprehensive presentation available on
metal toxicology. It discusses not only metals but also the toxic
endpoints, such as neurotoxicity, renal toxicity, and cancer
induction. Chapters are written by experts in their respective
fields, focusing on carcinogenesis and human exposures and
highlighting the major aspects and issues of toxicity in general.
Features that characterize the aging process include the gradual
accumulation of cell damage after prolonged exposure to oxidative
and inflammatory events over a lifetime. In addition to the
accretion of lesions, the intrinsic levels of pro-oxidant and
aberrant immune responses are elevated with age. These adverse
events are often further enhanced by the chronic and slow
progressing diseases that characterize the senescent brain and
cardiovascular system. The incidence of some disorders such as
Alzheimer's disease and vascular diseases are sufficiently
prevalent in the extreme elderly that these disorders can arguably
be considered "normal." Aging and Aging-Related Disorders examines
the interface between normal and pathological aging, and
illustrates how this border can sometimes be diffuse. It explores
and illustrates the processes underlying the means by which aging
becomes increasingly associated with inappropriate levels of free
radical activity and how this can serve as a platform for the
progression of age-related diseases. The book provides chapters
that examine the interactive relationship between systems in the
body that can enhance or sometimes even limit cellular longevity.
In addition, specific redox mechanisms in cells are discussed.
Another important aspect for aging discussed here is the close
relationship between the systems of the body and exposure to
environmental influences of oxidative stress that can affect both
cellular senescence and a cell's nuclear DNA. What may be even more
interesting to note is that these external stressors are not simply
confined to illnesses usually associated with aging, but can be
evident in maturing and young individuals. A broad range of
internationally recognized experts have contributed to this book.
Their aim is to successfully highlight emerging knowledge and
therapy for the understanding of the basis and development of aging
related disorders.
Features that characterize the aging process include the gradual
accumulation of cell damage after prolonged exposure to oxidative
and inflammatory events over a lifetime. In addition to the
accretion of lesions, the intrinsic levels of pro-oxidant and
aberrant immune responses are elevated with age. These adverse
events are often further enhanced by the chronic and slow
progressing diseases that characterize the senescent brain and
cardiovascular system. The incidence of some disorders such as
Alzheimer's disease and vascular diseases are sufficiently
prevalent in the extreme elderly that these disorders can arguably
be considered "normal". Aging and Aging-Related Disorders examines
the interface between normal and pathological aging, and
illustrates how this border can sometimes be diffuse. It explores
and illustrates the processes underlying the means by which aging
becomes increasingly associated with inappropriate levels of free
radical activity and how this can serve as a platform for the
progression of age-related diseases. The book provides chapters
that examine the interactive relationship between systems in the
body that can enhance or sometimes even limit cellular longevity.
In addition, specific redox mechanisms in cells are discussed.
Another important aspect for aging discussed here is the close
relationship between the systems of the body and exposure to
environmental influences of oxidative stress that can affect both
cellular senescence and a cell's nuclear DNA. What may be even more
interesting to note is that these external stressors are not simply
confined to illnesses usually associated with aging, but can be
evident in maturing and young individuals. A broad range of
internationally recognized experts have contributed to this book.
Their aim is to successfully highlight emerging knowledge and
therapy for the understanding of the basis and development of
aging-related disorders.
This volume offers the most comprehensive presentation available on
metal toxicology. It discusses not only metals but also the toxic
endpoints, such as neurotoxicity, renal toxicity, and cancer
induction. Chapters are written by experts in their respective
fields, focusing on carcinogenesis and human exposures and
highlighting the major aspects and issues of toxicity in general.
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