Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use. Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering.

This volume brings together, in a central text, chapters written by leading scholars working at the intersection of modeling, the natural and social sciences, and public participation. This book presents the current state of knowledge regarding the theory and practice of engaging stakeholders in environmental modeling for decision-making, and includes basic theoretical considerations, an overview of methods and tools available, and case study examples of these principles and methods in practice. Although there has been a significant increase in research and development regarding participatory modeling, a unifying text that provides an overview of the different methodologies available to scholars and a systematic review of case study applications has been largely unavailable. This edited volume seeks to address a gap in the literature and provide a primer that addresses the growing demand to adopt and apply a range of modeling methods that includes the public in environmental assessment and management. The book is divided into two main sections. The first part of the book covers basic considerations for including stakeholders in the modeling process and its intersection with the theory and practice of public participation in environmental decision-making. The second part of the book is devoted to specific applications and products of the various methods available through case study examination. This second part of the book also provides insight from several international experts currently working in the field about their approaches, types of interactions with stakeholders, models produced, and the challenges they perceived based on their practical experiences.

In Africa, a child wanders too far into the Knysna Forest. He never returns. Nine years later, two government officials, working on a census, find a white child living with a coloured family in the mountains on the other side of the forest. They take him away from the stricken Fiela, who has brought him up, and give him back to his 'original' family. Whipped into using a new name and calling strangers 'ma' and 'pa', Benjamin is so stunned that he cannot cry and waits for Fiela to reclaim him. But Fiela, powerless before authority, never comes. So Benjamin has to grow up before he can go in search of the truth.

Born and bred into the tawny magnificence of Africa, Saul would fight to save the vanishing world of his inheritance. Home of the wild elephants and the fiercely independent families of woodcutters, the Knysna forest is under threat from the exploitative greed of the timber merchants, and the ruthless plundering of the ivory hunters. Saul Barnard is a man with a self imposed mission - to halt the wanton destruction. For years he has protected the forest from intruders, finding a strange mystical kinship with the spirit of Old Foot, the indomitable and majestic elephant. Then when the word goes round that Old Foot is on the rampage, Saul is propelled towards a terrible confrontation that will change his future, for ever.

This book examines how the expansion of a steam-powered Royal Navy from the second half of the nineteenth century had wider ramifications across the British Empire. In particular, it considers how steam propulsion made vessels utterly dependent on a particular resource - coal - and its distribution around the world. In doing so, it shows that the 'coal question' was central to imperial defence and the protection of trade, requiring the creation of infrastructures that spanned the globe. This infrastructure required careful management, and the processes involved show the development of bureaucracy and the reliance on the 'contractor state' to ensure this was both robust and able to allow swift mobilisation in war. The requirement to stop regularly at foreign stations also brought men of the Royal navy into contact with local coal heavers, as well as indigenous populations and landscapes. These encounters and their dissemination are crucial to our understanding of imperial relationships and imaginations at the height of the imperial age.

Membranes are an energy efficient separation technology that are now the basis for many water treatment and food processing applications. However, there is the potential to improve the operating performance of these separations and to extend the application of membranes to energy production, gas separations, organic solvent-based separations, and biomedical applications through novel membrane materials. This book contains 20 chapters written by leading academic researchers on membrane fabrication and modification techniques and provides a comprehensive overview on the recent developments of membrane technology. Membranes can be manufactured from a range of materials including polymeric compounds, and ceramic materials, and both these materials are considered in the book. There are 5 chapters on water and wastewater membranes that cover the fabrication of thin film (TFC) composite membranes for nanofiltration(NF)/reverse osmosis (RO)/forward osmosis (FO) applications, stimuli responsive membranes, electrospun membranes, porous ceramic membranes, and polymeric ultrafiltration (UF) manufacture and modification. There are another 6 chapters on gas separation that consider carbon membranes, zeolite membranes, silica template and metal oxide silica membranes, TFC membranes, silica membranes, and metal organic framework (MOF) membranes. Zeolite membranes are also considered for organic solvent applications, as are solvent-resistant membranes manufactured by phase inversion, ceramic-supported composite membranes, and ceramic NF membranes. The emerging areas of membranes for energy and biomedical applications have 3 and 2 chapters, respectively. Energy applications consider ion exchange membranes for use in fuel cells, membranes for electrodialysis, and membranes for use in microbial fuel cells. For biomedical applications the chapters focus on hemodialysis membranes and redox responsive membranes.

Dennis Brutus, Jeremy Cronin, Nuruddin Farah, Nadine Gordimer, Dan Jacobson, Tahar Ben Jelloun, Doris Lessing, Gcina Mhlope, Sheila Roberts, Sipho Sepamla, Veronique Tadjo: some of Africa s greatest authors here interviewed by Stephen Gray, himself a masterful writer, respected in the USA and Europe as well as in his home country. An indaba or get-together of twenty-three interviews with a wide range of African writers some of great documentary value (Guy Butler, Fatima Dike, Doris Lessing); some reprinted widely (Nadine Gordimer, Sipho Sepamla, Veronique Tadjo) and yet others presenting haunting interpretaions of the present (Nuruddin Farah, Michele Rakotoson, Sheila Roberts). The transcripts assembled here first appeared in several journals and newspapers, ranging from Publishers Weekly to the South African Mail & Guardian."

Membranes are an energy efficient separation technology that are now the basis for many water treatment and food processing applications. However, there is the potential to improve the operating performance of these separations and to extend the application of membranes to energy production, gas separations, organic solvent-based separations, and biomedical applications through novel membrane materials. This book contains 20 chapters written by leading academic researchers on membrane fabrication and modification techniques and provides a comprehensive overview on the recent developments of membrane technology. Membranes can be manufactured from a range of materials including polymeric compounds, and ceramic materials, and both these materials are considered in the book. There are 5 chapters on water and wastewater membranes that cover the fabrication of thin film (TFC) composite membranes for nanofiltration(NF)/reverse osmosis (RO)/forward osmosis (FO) applications, stimuli responsive membranes, electrospun membranes, porous ceramic membranes, and polymeric ultrafiltration (UF) manufacture and modification. There are another 6 chapters on gas separation that consider carbon membranes, zeolite membranes, silica template and metal oxide silica membranes, TFC membranes, silica membranes, and metal organic framework (MOF) membranes. Zeolite membranes are also considered for organic solvent applications, as are solvent-resistant membranes manufactured by phase inversion, ceramic-supported composite membranes, and ceramic NF membranes. The emerging areas of membranes for energy and biomedical applications have 3 and 2 chapters, respectively. Energy applications consider ion exchange membranes for use in fuel cells, membranes for electrodialysis, and membranes for use in microbial fuel cells. For biomedical applications the chapters focus on hemodialysis membranes and redox responsive membranes.

In his introduction to this collection, Stephen Gray states that `there can be no artistic grounds on which to uphold a belief that "short" implies "lesser"'; he goes on to make the point that `Fugard seems naturally to be most at ease when working in compact dense forms'. This collection brings together all the available shorter plays by Athol Fugard not accessible to readers and performers, and demonstrates through these plays the crucial stages of Fugard's development as a great man of the theatre.

This volume brings together, in a central text, chapters written by leading scholars working at the intersection of modeling, the natural and social sciences, and public participation. This book presents the current state of knowledge regarding the theory and practice of engaging stakeholders in environmental modeling for decision-making, and includes basic theoretical considerations, an overview of methods and tools available, and case study examples of these principles and methods in practice. Although there has been a significant increase in research and development regarding participatory modeling, a unifying text that provides an overview of the different methodologies available to scholars and a systematic review of case study applications has been largely unavailable. This edited volume seeks to address a gap in the literature and provide a primer that addresses the growing demand to adopt and apply a range of modeling methods that includes the public in environmental assessment and management. The book is divided into two main sections. The first part of the book covers basic considerations for including stakeholders in the modeling process and its intersection with the theory and practice of public participation in environmental decision-making. The second part of the book is devoted to specific applications and products of the various methods available through case study examination. This second part of the book also provides insight from several international experts currently working in the field about their approaches, types of interactions with stakeholders, models produced, and the challenges they perceived based on their practical experiences.