Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine.

Along with its companion volume on intraflagellar transport, this book provides researchers with a comprehensive and up-to-date source of methods for the analysis cilia and flagella, focusing primarily on approaches that have been devised or significantly extended since the last volume of Methods in Cell Biology on this topic (volume 47, 1995). Edited by Stephen M. King and Gregory J. Pazour, the newest installment of this highly acclaimed serial will serve as an essential addition to the study of cilia and flagella.

* Covers protocols for cilia and flagella across systems and species * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures

Cilia are highly conserved organelles that serve motile functions, sensory functions, or both. These organelles power cell movement, generate fluid flow in various organs, act as sensors of the extracellular environment and have been modified for various specialized tasks such as light reception and smell. Defects in these ubiquitous organelles lead to a broad array of human genetic disorders that range from polycystic kidney disease, retinal degeneration, epilepsy and infertility to developmental defects such as situs inversus and polydactyly. This volume is the third in a three-part series on cilia that focuses on the use of model organisms to gain insight into ciliary function and on the process of intraflagellar transport that is essential for the assembly and maintenance of ciliary structures.

* Includes both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Covers forward and reverse genetic analysis of IFT and biochemical methods to define the role of IFT components * Methods presented cover molecular, genetic, and biochemical approaches to ciliary function in model organisms"

Along with its companion volume on axonemal dynein-mediated motility, this book provides researchers with a comprehensive and up-to-date source of methods for the analysis cilia and flagella, focusing primarily on approaches that have been devised or significantly extended since the last volume of Methods in Cell Biology on this topic (volume 47, 1995). Edited by Stephen M. King and Gregory J. Pazour, the newest installment of this highly acclaimed serial will serve as an essential addition to the study of cilia and flagella.

* Covers protocols for cilia and flagella across systems and species * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures

Draws from a diverse range of literature, including history, philosophy, public administration, leadership, religion, and spirituality, to explore what it means to be an ethical and moral leader. Takes a deep dive into the many challenges of leadership, examining the continuing contrast between bureaucracy and democracy, the unique ethical and moral characteristics of nonprofit and faith-based organizations, and the globalization of organizations and institutions. Develops a more holistic and interdisciplinary understanding of ethical and moral leadership, required for more thoughtful theoretical and empirical research.

Draws from a diverse range of literature, including history, philosophy, public administration, leadership, religion, and spirituality, to explore what it means to be an ethical and moral leader. Takes a deep dive into the many challenges of leadership, examining the continuing contrast between bureaucracy and democracy, the unique ethical and moral characteristics of nonprofit and faith-based organizations, and the globalization of organizations and institutions. Develops a more holistic and interdisciplinary understanding of ethical and moral leadership, required for more thoughtful theoretical and empirical research.

While many introductory public administration textbooks contain a dedicated chapter on ethics, The Public Administration Profession is the first to utilize ethics as a lens for understanding the discipline. Analyses of the ASPA Code of Ethics are deftly woven into each chapter alongside complete coverage of the institutions, processes, concepts, persons, history, and typologies a student needs to gain a thorough grasp of public service as a field of study and practice. Features include: A significant focus on "public interests," nonprofit management, hybrid-private organizations, contracting out and collaborations, and public service at state and local levels. A careful examination of the role that religion may play in public servants' decision making, as well as the unignorable and growing role that faith-based organizations play in public administration and nonprofit management at large. End-of-chapter ethics case studies, key concepts and persons, and dedicated "local community action steps" in each chapter. Appendices dedicated to future public administration and nonprofit career management, writing successful papers throughout a student's career, and professional codes of ethics. A comprehensive suite of online supplements, including: lecture slides; quizzes and sample examinations for undergraduate and graduate courses containing multiple choice, true-false, identifications, and essay questions; chapter outlines with suggestions for classroom discussion; and suggestions for use of appendices, e.g., how to successfully write a short term paper, a brief policy memo, resume, or a book review. Providing students with a comprehensive introduction to the subject while offering instructors an elegant new way to bring ethics prominently into the curriculum, The Public Administration Profession is an ideal introductory text for public administration and public affairs courses at the undergraduate or graduate level.

Dyneins: The Biology of Dynein Motors, Second Edition, offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics and the consequences of defects for human biology, disease and development. This second edition is extensively revised, with coverage expanded from 24 to 42 chapters. Much of the expanded coverage occurs in Volume Two on dynein dysfunction and disease, such as the role of dynein and cancer, while Volume One covers the history and evolution of dyneins, dyneins in ciliary biology and cytoplasmic dynein biology.

Dyneins: Structure, Biology and Disease, Second Edition, offers a broad view of dyneins mechanics, dysfunction, and disease, providing an overview of dyneins from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development. To account for these enormous strides, the second edition is extensively revised. Additionally, the coverage has expanded from 24 to 42 chapters, and is now housed in two volumes. Much of the expanded coverage occurs in Volume 2 which focuses on dynein dysfunction and disease, such as the role of dynein and cancer. Volume 1 covers the history and evolution of dyneins, dyneins in ciliary biology, and cytoplasmic dynein biology, while Volume 2 covers the structure and mechanics of dynein motors and dynein dysfunction and disease.

While many introductory public administration textbooks contain a dedicated chapter on ethics, The Public Administration Profession is the first to utilize ethics as a lens for understanding the discipline. Analyses of the ASPA Code of Ethics are deftly woven into each chapter alongside complete coverage of the institutions, processes, concepts, persons, history, and typologies a student needs to gain a thorough grasp of public service as a field of study and practice. Features include: A significant focus on "public interests," nonprofit management, hybrid-private organizations, contracting out and collaborations, and public service at state and local levels. A careful examination of the role that religion may play in public servants' decision making, as well as the unignorable and growing role that faith-based organizations play in public administration and nonprofit management at large. End-of-chapter ethics case studies, key concepts and persons, and dedicated "local community action steps" in each chapter. Appendices dedicated to future public administration and nonprofit career management, writing successful papers throughout a student's career, and professional codes of ethics. A comprehensive suite of online supplements, including: lecture slides; quizzes and sample examinations for undergraduate and graduate courses containing multiple choice, true-false, identifications, and essay questions; chapter outlines with suggestions for classroom discussion; and suggestions for use of appendices, e.g., how to successfully write a short term paper, a brief policy memo, resume, or a book review. Providing students with a comprehensive introduction to the subject while offering instructors an elegant new way to bring ethics prominently into the curriculum, The Public Administration Profession is an ideal introductory text for public administration and public affairs courses at the undergraduate or graduate level.