The Political Economy of Bureaucracy applies Public Choice theory and a complex systems view of government institutions to analyze policy implementation as an economic process. It addresses the common and vexing question of why managing federal agencies for results is so difficult by challenging traditional assumptions of institutional design and policy analysis. Using creative methods that focus on relationships that constrain the choices of executives and managers in a political hierarchy, the author reveals control and coordination as goals that are imperfectly achieved and often conflicting with one another. Despite decades of intense study, serious reform efforts and impressive technological advances, the U.S. government remains a typical bureaucracy that fails to meet citizens' expectations. Clearly, policy analysis is missing something. The problem may rest with "machine" models of government. Rules, especially those governing expenditures, are assumed to be feasible and effective. Analysis of the federal government as a complex system of relationships between semi-autonomous agents helps explain the disconnect between policy and results. The solution is to roll back micro-management of ends and means; policymakers should focus on objectives and facilitate implementation by selectively relaxing constraints that prevent experimentation needed to determine the most effective methods. This book devotes unusual attention to the interaction between executive and legislative branches of government and between political appointees and career civil servants. Most studies of government policy take existing institutional structure for granted. Different conclusions emerge from this analysis by virtue of the systems view that accepts status quo hierarchies but questions the effectiveness of the rules that govern policy implementation. This book will be of interest to postgraduates and researchers focussing on Economic Theory, Public Choice, Institutional Economics and Political Science, as well as to those working in the public sector interested in Public Administration, Public Policy, and Organizational Behavior.

The Political Economy of Bureaucracy applies Public Choice theory and a complex systems view of government institutions to analyze policy implementation as an economic process. It addresses the common and vexing question of why managing federal agencies for results is so difficult by challenging traditional assumptions of institutional design and policy analysis. Using creative methods that focus on relationships that constrain the choices of executives and managers in a political hierarchy, the author reveals control and coordination as goals that are imperfectly achieved and often conflicting with one another. Despite decades of intense study, serious reform efforts and impressive technological advances, the U.S. government remains a typical bureaucracy that fails to meet citizens' expectations. Clearly, policy analysis is missing something. The problem may rest with "machine" models of government. Rules, especially those governing expenditures, are assumed to be feasible and effective. Analysis of the federal government as a complex system of relationships between semi-autonomous agents helps explain the disconnect between policy and results. The solution is to roll back micro-management of ends and means; policymakers should focus on objectives and facilitate implementation by selectively relaxing constraints that prevent experimentation needed to determine the most effective methods. This book devotes unusual attention to the interaction between executive and legislative branches of government and between political appointees and career civil servants. Most studies of government policy take existing institutional structure for granted. Different conclusions emerge from this analysis by virtue of the systems view that accepts status quo hierarchies but questions the effectiveness of the rules that govern policy implementation. This book will be of interest to postgraduates and researchers focussing on Economic Theory, Public Choice, Institutional Economics and Political Science, as well as to those working in the public sector interested in Public Administration, Public Policy, and Organizational Behavior.

Articular cartilage is a unique and highly specialized avascular connective tissue in which the availability of oxygen and glucose is significantly lower than synovial fluid and plasma. Glucose is an essential source of energy during embryonic growth and fetal development and is vital for mesenchymal cell differentiation, chondrogenesis and skeletal morphogenesis. Glucose is an important metabolic fuel for differentiated chondrocytes during post-natal development and in adult articular cartilage and is a common structural precursor for the synthesis of extracellular matrix glycosaminoglycans. Glucose metabolism is critical for growth plate chondrocytes which participate in long bone growth. Glucose concentrations in articular cartilage can fluctuate depending on age, physical activity and endocrine status. Chondrocytes are glycolytic cells and must be able to sense the concentration of oxygen and glucose in the extracellular matrix and respond appropriately by adjusting cellular metabolism. Consequently chondrocytes must have the capacity to survive in an extracellular matrix with limited nutrients and low oxygen tensions. Published data from our laboratories suggest that chondrocytes express multiple isoforms of the GLUT/SLC2A family of glucose/polyol transporters. In other tissues GLUT proteins are expressed in a cell-specific manner, exhibit distinct kinetic properties, and are developmentally regulated. Several GLUTs expressed in chondrocytes are regulated by hypoxia, hypoxia mimetics, metabolic hormones and pro-inflammatory cytokines. In this multidisciplinary article we review the molecular and morphological aspects of GLUT expression and function in chondrocytes and their mesenchymal and embryonic stem cell precursors and propose key roles for these proteins in glucose sensing and metabolic regulation in cartilage.

Written expressly for undergraduate and graduate geologists, this book focuses on how geochemical principles can be used to solve practical problems. The attention to problem-solving reflects the authors'belief that showing how theory is useful in solving real-life problems is vital for learning. The book gives students a thorough grasp of the basic principles of the subject, balancing the traditional equilibrium perspective and the kinetic viewpoint.

The first half of the book considers processes in which temperature and pressure are nearly constant. After introductions to the laws of thermodynamics, to fundamental equations for flow and diffusion, and to solution chemistry, these principles are used to investigate diagenesis, weathering, and natural waters. The second half of the book applies thermodynamics and kinetics to systems undergoing changes in temperature and pressure during magmatism and metamorphism. This revised edition incorporates new geochemical discoveries as examples of processes and pathways, with new chapters on mineral structure and bonding and on organic matter and biomarkers. Each chapter has worked problems, and the authors assume that the student has had a year of college-level chemistry and a year of calculus.

Praise for the first edition

"A truly modern geochemistry book.... Very well written and quite enjoyable to read.... An excellent basic text for graduate level instruction in geochemistry." -- "Journal of Geological Education"

"An up-to-date, broadly conceived introduction to geochemistry.... Given the recent flowering of geochemistry as an interdisciplinary science, and given the extent to which it now draws upon the fundamentals of thermodynamics and kinetics to understand earth and planetary processes, this timely and rigorous book] is welcome indeed." -- "Geochimica et Cosmochimica Acta"

"Embracing Destiny's Crossroads" is: The unveiling of the author's real life journey that goes beyond her autobiography in revealing simple life's lessons on what to do when reaching crossroads in your life.