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The objective of this book is to catalyze the application of
genomics to the diagnosis and treatment of oral diseases by
comprehensively presenting focused discussions on the current state
of knowledge. The first section book provides basic
information about genetics, genomics and personalized medicine and
the informatical methods available to apply and organize genetic
data so that it has clinical relevance. Recognizing the
genetic robustness of the oral cavity, the introductory
section includes chapters on the oral micro biome and host
genomics and response to infectious agents. The next two
sections contain chapters which describe the genomics of
specific oral diseases and conditions, including the genetic basis
for mechanism and risk of treatment toxicities associated with
cancer therapy and bisphosphonates. Four chapters focus on
gene-based therapies and the pharmacogenomics applied to oral
disease. The final chapter presents a provocative summary
which describes a comprehensive vision of the melding of genomics
to personalized medicine and the potential actionable outcomes that
will likely affect clinical practice in the upcoming years.
The objective of this book is to catalyze the application of
genomics to the diagnosis and treatment of oral diseases by
comprehensively presenting focused discussions on the current state
of knowledge. The first section book provides basic information
about genetics, genomics and personalized medicine and the
informatical methods available to apply and organize genetic data
so that it has clinical relevance. Recognizing the genetic
robustness of the oral cavity, the introductory section includes
chapters on the oral micro biome and host genomics and response to
infectious agents. The next two sections contain chapters which
describe the genomics of specific oral diseases and conditions,
including the genetic basis for mechanism and risk of treatment
toxicities associated with cancer therapy and bisphosphonates. Four
chapters focus on gene-based therapies and the pharmacogenomics
applied to oral disease. The final chapter presents a provocative
summary which describes a comprehensive vision of the melding of
genomics to personalized medicine and the potential actionable
outcomes that will likely affect clinical practice in the upcoming
years.
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