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The obesity pandemic continues to increase on a world-wide basis
with over 70% of the United States population being either
overweight or obese. Hematologic malignancies have recently been
identified among the obesity associated malignancies spanning the
lifespan from childhood to the elderly and include leukemia,
myeloma, lymphoma and others. In addition to the etiologic
association between obesity and hematologic malignancies, the
presence of obesity has profound effects on therapy by impacting
pharmacokinetics of chemotherapeutic agents, dose, adipocyte
metabolism and drug distribution. These may be particularly
important in hematopoietic stem cell transplantation. Another
important aspect of the association of obesity with hematologic
malignancies is the increased incidence of obesity in children who
successfully complete therapy for acute lymphoblastic leukemia.
This and other observations indicate important relations between
the hematopoietic systems and fat metabolism. This volume on Energy
Balance in Hematologic Malignancies will provide an important
volume in this series and a basis for better understanding
etiology, mechanisms, therapeutics implications and experimental
approaches. This volume of energy balance and cancer will focus on
the relation of obesity to hematologic malignancies, the
epidemiology, potential mechanisms, and thereapeutic considerations
including effects on pharmacologic and physical approaches as well
as the delayed effects of therapy on energy balance.
The obesity pandemic continues to increase on a world-wide basis
with over 70% of the United States population being either
overweight or obese. Hematologic malignancies have recently been
identified among the obesity associated malignancies spanning the
lifespan from childhood to the elderly and include leukemia,
myeloma, lymphoma and others. In addition to the etiologic
association between obesity and hematologic malignancies, the
presence of obesity has profound effects on therapy by impacting
pharmacokinetics of chemotherapeutic agents, dose, adipocyte
metabolism and drug distribution. These may be particularly
important in hematopoietic stem cell transplantation. Another
important aspect of the association of obesity with hematologic
malignancies is the increased incidence of obesity in children who
successfully complete therapy for acute lymphoblastic leukemia.
This and other observations indicate important relations between
the hematopoietic systems and fat metabolism. This volume on Energy
Balance in Hematologic Malignancies will provide an important
volume in this series and a basis for better understanding
etiology, mechanisms, therapeutics implications and experimental
approaches. This volume of energy balance and cancer will focus on
the relation of obesity to hematologic malignancies, the
epidemiology, potential mechanisms, and thereapeutic considerations
including effects on pharmacologic and physical approaches as well
as the delayed effects of therapy on energy balance.
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