A clear, comprehensive treatment of the subject, Environmental Statistics with S-PLUS is an ideal resource for environmental scientists, engineers, regulators, and students, even those with only a limited knowledge of statistics. It provides insight into what to think about before you collect environmental data, how to collect it, and how to make sense of it after you have it. This book addresses the vast array of methods used today by scientists, researchers, and regulators.

Through its convenient showcase of information and numerous data sets posted on the Web, Environmental Statistics with S-PLUS shows you how to implement these methods using the statistical software package S-PLUS and the add-in modules EnvironmentalStats for S-PLUS, S+SpatialStats, and S-PLUS for ArcView. This survey of statistical methods, definitions, and concepts helps you collect and effectively analyze data for environmental pollution problems.

Each year hundreds of new drugs are approved for the marketplace. The approval of a single new drug is the result of years of screening tens of thousands of compounds, performing pre-clinical research on their effects, and designing, implementing, and analyzing the results of clinical trials. This book provides a general guide to statistical methods used in the pharmaceutical industry, and is aimed at graduate students and researchers who want to know more about statistical applications in all phases of the drug development process. The 19 chapters authored by over 30 statisticians working in the industry follow the general sequence of drug development, from pre-clinical research and saftey assessment to dose finding, safety studies, large clinical trials, analysis of health economic data, and fianlly manufacturing and production. Special topics such as single patient analysis and the impact of patient compliance show the broad spectrum of applications of data analysis methods. Each chapter illustrates a practical problem using data from actual studies by describing the study, the data, the methods, and the results. All of the analyses are done with S-PLUS, and the data and code are provided both in appendices to the chapters and on the companion Springer-Verlag web site, making it possible to reproduce the results and extend the analyses. Prior knowledge of the software is not required to follow the analyses. Steven P. Millard is a statistical consultant and also Manager of Consulting Services for MathSoft, Inc. (Data Analysis Products Division.) He has applied statistical methods to projects ranging from quality control in bioassay to measuring water quality to automating home appraisal, and has taught courses in S-PLUS for over 10 years. He is the author of the book Environmental Statistics with S-PLUS (CRC Press) as well as the S-PLUS add-in module ENVIRONMENTALSTATS for S-PLUS. Andreas Krause is a statistical consultant in the pharmaceutical industry and works for Novartis Pharma AG. He has extensive experience in graphical and numerical data analysis as well as programming, has taught numerous classes with and on S-PLUS, and is an S_PLUS user from the early days on. He is also author of the book The Basics of S and S-PLUS (Springer).

A clear, comprehensive treatment of the subject, Environmental Statistics with S-PLUS surveys the vast array of statistical methods used to collect and analyze environmental data. The book explains what these methods are, how to use them, and where to find references to them. In addition, it provides insight into what to think about before you collect environmental data, how to collect the data, and how to make sense of it after collection. A unique and powerful feature of the book is its integration with the commercially available software package S-Plus and the add-on modules EnvironmentalStats for S-PLUS, S+SpatialStats, and S-PLUS for ArcView. The book presents data sets to explain statistical methods, and then shows how to implement these methods by providing the commands for and the results from the software. This survey of statistical methods, definitions, and concepts helps you collect and effectively analyze data for environmental pollution problems. Using the S-PLUS software in conjunction with this text will no doubt increase understanding of the methods.

This book describes EnvStats, a new comprehensive R package for environmental statistics and the successor to the S-PLUS module EnvironmentalStats for S-PLUS (first released in 1997). EnvStats and R provide an open-source set of powerful functions for performing graphical and statistical analyses of environmental data, bringing major environmental statistical methods found in the literature and regulatory guidance documents into one statistical package, along with an extensive hypertext help system that explains what these methods do, how to use these methods, and where to find them in the environmental statistics literature. EnvStats also includes numerous built-in data sets from regulatory guidance documents and the environmental statistics literature.
This book shows how to use EnvStats and R to easily:
* graphically display environmental data
* plot probability distributions
* estimate distribution parameters and construct confidence intervals on the original scale for commonly used distributions such as the lognormal and gamma, as well as do this nonparametrically
* estimate and construct confidence intervals for distribution percentiles or do this nonparametrically (e.g., to compare to an environmental protection standard)
* perform and plot the results of goodness-of-fit tests
* compute optimal Box-Cox data transformations
* compute prediction limits and simultaneous prediction limits (e.g., to assess compliance at multiple sites for multiple constituents)
* perform nonparametric estimation and test for seasonal trend (even in the presence of correlated observations)
* perform power and sample size computations and create companion plots for sampling designs based on confidence intervals, hypothesis tests, prediction intervals, and tolerance intervals
* deal with non-detect (censored) data
* perform Monte Carlo simulation and probabilistic risk assessment* reproduce specific examples in EPA guidance documents
EnvStats combined with other R packages (e.g., for spatial analysis) provides the environmental scientist, statistician, researcher, and technician with tools to get the job done
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Each year hundreds of new drugs are approved for the marketplace. The approval of a single new drug is the result of years of screening tens of thousands of compounds, performing pre-clinical research on their effects, and designing, implementing, and analyzing the results of clinical trials. This book provides a general guide to statistical methods used in the pharmaceutical industry, and is aimed at graduate students and researchers who want to know more about statistical applications in all phases of the drug development process. The 19 chapters authored by over 30 statisticians working in the industry follow the general sequence of drug development, from pre-clinical research and saftey assessment to dose finding, safety studies, large clinical trials, analysis of health economic data, and fianlly manufacturing and production. Special topics such as single patient analysis and the impact of patient compliance show the broad spectrum of applications of data analysis methods. Each chapter illustrates a practical problem using data from actual studies by describing the study, the data, the methods, and the results. All of the analyses are done with S-PLUS, and the data and code are provided both in appendices to the chapters and on the companion Springer-Verlag web site, making it possible to reproduce the results and extend the analyses. Prior knowledge of the software is not required to follow the analyses. Steven P. Millard is a statistical consultant and also Manager of Consulting Services for MathSoft, Inc. (Data Analysis Products Division.) He has applied statistical methods to projects ranging from quality control in bioassay to measuring water quality to automating home appraisal, and has taught courses in S-PLUS for over 10 years. He is the author of the book Environmental Statistics with S-PLUS (CRC Press) as well as the S-PLUS add-in module ENVIRONMENTALSTATS for S-PLUS. Andreas Krause is a statistical consultant in the pharmaceutical industry and works for Novartis Pharma AG. He has extensive experience in graphical and numerical data analysis as well as programming, has taught numerous classes with and on S-PLUS, and is an S_PLUS user from the early days on. He is also author of the book The Basics of S and S-PLUS (Springer).