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The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM)
has attracted the interest of our group during the last three
decades. As early as 1969, a Nobel Symposium dealing with this
topic was organized in Stockholm. This was followed in 1987 by a
Nobel Conference devoted to the same subject. The main purpose of
these meetings was to bring together the most distinguished
scientists from all over the world and present theories on
molecular and genetic mechanisms responsible for the development of
glucose intolerance in NIDDM. This idea was followed also in the
present symposium, "New Concepts in the Pathogenesis of NIDDM,"
organized with diabetologists from Toronto in Canada. Our purpose
is to biannually organize international meetings covering important
aspects of dia betes research, hoping that this type of interaction
may result in new concepts and treat ment alternatives. For us,
participating in this symposium in September 1992, the meeting in
Stockholm was very stimulating and innovative. It is a special
pleasure that almost all invited lecturers submitted manuscripts.
Thus, the publication of the proceedings of the symposium makes it
possible for all interested in diabetes research to share new ideas
and findings presented at the meeting. Claes-G6ran Ostenson Suad
Efendic Mladen V ranic v CONTENTS REGULATION OF INSULIN SECRETION
Impaired Glucose-Induced Insulin Secretion: Studies in Animal
Models with Spontaneous NIDDM . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . C. -G.
Ostenson, A. Khan, and S. Efendic Perturbation ofIslet Metabolism
and Insulin Release in NIDDM. . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . 13 WJ. Malaisse 2 Regulation of Cytoplasmic
Free Ca+ in Insulin-Secreting Cells. . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . ."
This book has a dual purpose, to review in depth the control of
fuel homeostasis in the brain and the role of the nervous system in
the control of fuel deposition in the body. From the methodological
point of view the emphasis is on the application of advanced
technologies to assess fuel transport and brain metabolism, the
role of peptides in the neuroendocrine system and the response of
the brain to hypoglycemia. These technologies include positron
emmission tomography, nuclear magnetic resonance,
immunocytochemistry, molecular biology, autoradiography. To study
fuel homeostasis in the body advanced tracer methods that include
modelling are set out. From the pathophysiological point of view
the emphasis is on abnormalities in stress, brain metabolism in
diabetes, eating and degenerative disorders. This book contains
contributions from endocrinologists, physiologists, neurologists,
psychoneuroendocrinOlogists, biophysicists, biochemists and experts
in nutrition. This authorship represents a unique diversity of
researchers who, for the first time, cover comprehensively the
interaction between the nervous system and fuel homeostasis, both
in health and disease. We hope this book will be an important
source of information for both researchers and practicing
clinicians. Mladen Vranic Suad Efendic Charles Hollenberg v
ACKNOWLEDGEMENTS The Symposium from which this volume arose
(University of Toronto, June 27-28, 1990) was the first
Toronto-Stockholm symposium on Perspectives in Diabetes Research.
These Symposia are organized triennially by the Banting and Best
Diabetes Centre, University of Toronto and the Department of
Endocrinology, Karolinska Institute, Stockholm.
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