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Bronchopulmonary dysplasia (BPD) as a chronic lung disease
affecting preterm infants has been recognized for more than 45
years. However, little progress has been made in the prevention and
treatment of the disease. BPD continues to be a major morbidity
affecting preterm infants. Studies in pre-adolescent children
demonstrate that the abnormal lung function from BPD persists well
into childhood. Infants with BPD also have an increased risk for
adverse neurodevelopmental outcome. Thus BPD imposes a significant
burden of adverse health outcomes in preterm infants. The major
risk factors for BPD are prematurity, mechanical ventilation,
exposure to noxious insults such as oxygen, infections. New
research data both in basic science and clinical studies have shed
light on the pathogenesis, and possible new treatment or management
strategies for the future. In the proposed issue of the Clinics in
Perinatology, we would like to comprehensively cover BPD both from
a basic science and clinical perspective. Our attempt is to balance
new information along with classic topics. The proposed authors for
the issue are recognized experts in the topic area/s. We hope that
the issue will be of interest to a broad array of readership.
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