This book constitutes the proceedings of the 6th IFIP TC 12 International Conference on Computational Intelligence in Data Science, ICCIDS 2023, which took place in Kalavakkam, India, in  February  2023. The 24 full papers presented in this volume were carefully reviewed and selected from 134 submissions. The major theme of the conference was intended to be computation intelligence and knowledge management. Various emerging areas like IoT, cyber security and data science need computation intelligence to align with the cutting-edge research. Machine learning delivers insights hidden in data for rapid, automated responses and improved decision making. Machine learning for IoT can be used to project future trends, detect anomalies, and augment intelligence by ingesting image, video, and audio.