This volume constitutes reviewed and selected papers from the 11th International Advanced Computing Conference, IACC 2021, held in December 2021. The 47 full papers and 4 short papers presented in the volume were thorougly reviewed and selected from 246 submissions. The papers are organized in the following topical sections: application of artificial intelligence and machine learning in healthcare; application of AI for emotion and behaviour prediction; problem solving using reinforcement learning and analysis of data; advance uses of RNN and regression techniques; special intervention of AI.