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Polymeric materials are now playing an increasingly important role
in pharmaceuticals, as well as in sensing devices, in situ
prostheses and probes, and microparticle diagnostic agents. This
new volume consists of twenty-two recent research-based reports on
the developments in these areas of pharmaceutical and biomaterials
technology. The reports were prepared by top scientists in the
field and are based on current research conducted at leading
laboratories in the U.S.A., Europe, and Asia. These 22 chapters
report the latest information in the application of polymers to
biological systems.
Emphasizing its uses in cancer and cardiovascular and autoimmune
diseases, Pharmaceutical Perspectives of Nucleic Acid-Based Therapy
presents a comprehensive account of gene therapy, from development
in the laboratory to clinical applications. Internationally
acclaimed scientists discuss the potential use of lipids, peptides
and polymers for the in vivo delivery of nucleic acids, the genesis
of structure-synthesis-function interrelationships and the
evolutionary approaches of these gene carriers. The book also
addresses the influence of a viable gene expression system on
disease by controlling gene regulation, transcription, translation
and replication.
Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics presents a comprehensive account of gene therapy, from development in the laboratory, to clinical applications, with an emphasis on cardiovascular and autoimmune diseases as well as cancer. Several internationally acclaimed scientists discuss the potential use of lipids, peptides and polymers for the in vivo delivery of nucleic acids, the genesis of structure-synthesis-function interrelationships and the evolutionary approaches of these gene carriers. How the components of a viable gene expression system would influence the disease state by controlling gene regulation, transcription, translation and replication are also systematically addressed. eBook available with sample pages: 0203300963
The evident rapid expansion of scientific work and intense interest
in both experimental and clinical aspects of new drug delivery
systems provided strong motivation for planning this symposium. In
designing the program, speakers were identified for their
particular expertise in a wide range of topics such as dermal
delivery systems, pro-drugs, oral prolonged release,
rate-controlled drug delivery, the pharmacokinetics of drug release
systems, the synthesis of polymeric drug carriers and the
refinement of drug delivery pumps. Because of the considerable
involvement of diverse scientists from laboratories around the
world where investigations relevant to the topic are now being
pursued, a deliberate effort was made to invite international
leaders in the field to share their knowledge and experimental
outcomes. Thus, plenary papers and panel discussions were offered
by organic chemists, bioengineers, patholo gists, material
scientists, physical chemists, and pharmacokineti cists from
academic and industrial laboratories in some dozen countries. This
book which records the presentations offered at the sym posium
covers a broad array of topics ranging from general overviews of
the physicochemical concepts and analytical methodology which
underpin the refinement of drug delivery systems and the tissue
responses associated with the use of such systems through detailed
discussions of a variety of current approaches employed in the
development of new systems.
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