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Sustained release of macromolecular drugs from polymeric matrices
has received increasing attention in recent years. Vaccines that
are required to be given in multiple divided doses are not
efficacious if only one dose is given without boosting. In order to
be effective, most vaccines require two or three booster doses
after primary immunization. Therefore, the conversion of multiple
dose vaccines into single dose vaccines may represent an important
advance. Among the various tentative for improving the
administration of proteins, the microencapsulation into
biodegradable polymers represents a practical and promising
approachControlled drug delivery technology using biodegradable
polymers as carriers represents one of the most rapidly advancing
area of science.
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