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Tailoring or modulation of drug release from delivery systems
comprises a major area of research in pharmaceutical field where
the primary objective is to either sustain drug release or to
design orodispersible tablets. This objective can be successfully
achieved by use of a class of natural excipients - gums and
mucilages. These polysaccharidic plant-derived biopolymers because
of their unique swellability in aqueous medium can exert a
retardant effect on drug release or can act as superdisintegrant,
depending on the concentration used in the formulation. Mechanism
of drug release from hydrophilic matrices consisting of gums and
mucilages is based on solvent penetration-induced polymer
relaxation, diffusion of entrapped drug followed by degradation or
erosion of the matrix. The degree and time-scale of swelling
contributes significantly to the kinetics of drug release. Drug
diffusion from polysaccharidic hydrogel may be of either Fickian,
Case II or anomalous transport type. The book has been designed to
highlight on the bifunctional aspect of the natural gums primarily
because of their concentration-dependent effect on drug release and
their high degree of swellability.
The duration of diabetes, and fasting blood sugar values were
significantly higher in patients with diabetes with severe CAN.
Prolongation of QTC interval correlates well with degree of cardiac
autonomic neuropathy in diabetics. QTC prolongation may be
considered as pointer towards diabetic cardiac autonomic neuropathy
in the busy outpatient setting where it is not possible to perform
the conventional battery of tests. Recognition of QTC prolongation
may help identify diabetics with a high risk of sudden cardiac
death. Trying to manage diabetes is hard because if you don't,
there are consequences you'll have to deal with later in life."
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