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The field of extracellular vesicles (EVs) has progressed immensely
in recent times with evidences highlighting their importance in
physiology and pathology. This book entails extensive reflective
literature on many subtypes of EVs including exosomes, exomeres,
ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The
book further discusses the biogenesis and secretion of these EVs,
detailing the biological pathways and proteins involved. Research
investigating the biological functions of EVs is rapidly increasing
and the current knowledge around their role in progression of
diseases such as cancer, neurodegeneration and metabolic disorders
is discussed in multiple chapters. The implications of EVs in
intercellular communication and the significance of biologically
active cargo carried within these EVs are further examined.
Moreover, the numerous applications of EVs in diagnostics and
treatment of diseases are reviewed in detail, particularly their
potential as biomarkers and drug delivery vehicles. Taken together,
this book is a compilation of the key implications of EVs that are
secreted by virtually all cell types. Readers will gain a
perspective into the biology, functions and applications of EVs and
their constantly evolving knowledge base.
This thorough book covers the most recent proteomics techniques,
databases, bioinformatics tools, and computational approaches that
are used for the identification and functional annotation of
proteins and their structure. The most recent proteomic resources
widely used in the biomedical scientific community for storage and
dissemination of data are discussed. In addition, specific MS/MS
spectrum similarity scoring functions and their application in the
field of proteomics, statistical evaluation of labeled comparative
proteomics using permutation testing, and methods of phylogenetic
analysis using MS data are also described in detail. Written for
the highly successful Methods in Molecular Biology series, chapters
contain the kind of detail and key implementation advice to ensure
successful results. Authoritative and cutting-edge, Proteome
Bioinformatics serves as a useful resource for researchers who are
beginners as well as advanced investigators in the field of
proteomics.
This thorough book covers the most recent proteomics techniques,
databases, bioinformatics tools, and computational approaches that
are used for the identification and functional annotation of
proteins and their structure. The most recent proteomic resources
widely used in the biomedical scientific community for storage and
dissemination of data are discussed. In addition, specific MS/MS
spectrum similarity scoring functions and their application in the
field of proteomics, statistical evaluation of labeled comparative
proteomics using permutation testing, and methods of phylogenetic
analysis using MS data are also described in detail. Written for
the highly successful Methods in Molecular Biology series, chapters
contain the kind of detail and key implementation advice to ensure
successful results. Authoritative and cutting-edge, Proteome
Bioinformatics serves as a useful resource for researchers who are
beginners as well as advanced investigators in the field of
proteomics.
The field of extracellular vesicles (EVs) has progressed immensely
in recent times with evidences highlighting their importance in
physiology and pathology. This book entails extensive reflective
literature on many subtypes of EVs including exosomes, exomeres,
ectosomes, apoptotic vesicles, bacterial EVs and fungal EVs. The
book further discusses the biogenesis and secretion of these EVs,
detailing the biological pathways and proteins involved. Research
investigating the biological functions of EVs is rapidly increasing
and the current knowledge around their role in progression of
diseases such as cancer, neurodegeneration and metabolic disorders
is discussed in multiple chapters. The implications of EVs in
intercellular communication and the significance of biologically
active cargo carried within these EVs are further examined.
Moreover, the numerous applications of EVs in diagnostics and
treatment of diseases are reviewed in detail, particularly their
potential as biomarkers and drug delivery vehicles. Taken together,
this book is a compilation of the key implications of EVs that are
secreted by virtually all cell types. Readers will gain a
perspective into the biology, functions and applications of EVs and
their constantly evolving knowledge base.
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