Homeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system - including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.

Homeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system - including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.

The Secrets of The Universe- Universal Laws, Past Lives, Ghost Adventures and More is the fifth book from Susan Masino, author of The Story of AC/DC-Let There Be Rock, now in 10 languages and Family Tradition- Three Generations of Hank Williams. In her new book, Masino explores her lifelong passion of the Universe and how it works. The Secrets of the Universe investigates synchronicity, positive manifestation, healing with light, numerology, past lives and ghost adventures. Masino has given public speeches on synchronicity for the Unexplained Research team conferences based in Wisconsin. She has also studied numerology, and participated in ghost hunts in numerous locations including a brothel in Deadwood, South Dakota and the famed Bobby Mackey's bar in Wilder, KY. "If you want to find the secrets of the Universe, think in terms of energy, frequency and vibration."-Nikola Tesla

(Book). Covering three generations of Hank Williams, Family Tradition is both unique and vast in scope. Beginning in the present day with Hank III who gave the author unprecedented access and time-traveling across the years, this examines just what kind of rebel mojo inspired this crazed family of country music, from Hank Sr. often regarded as one of the most influential of American musicians to Hank Jr., to this year's model, Hank III, who has somehow found a way to reconcile his legacy's deep-rooted twang and high-lonesome sound with particularly searing strains of punk and heavy metal, launching an all-out war with traditional Nashville in the process. (a href="http: //halleonardbooks.com/viewaudio.do?itemId=00332839&fileName=http: //s3.amazonaws.com/halleonard-closerlook/00332839/MasinoPodcast.mp3" target="_blank")Listen to Susan Masino live at Book Expo America on the BEA Podcast.(/a)