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You see things, and sa)' why? But I dream 1hings that never were,
and I say, 11'hy 110t? George Bernhard Shaw Far ahead of his time,
June 1st, 1909, Alexander Maximov communicated in a lecture, given
in the Charite in Berlin, the fundamental knowledge, that there
exists a lymphoid hemopoetic stem cell. Alexander Friedenstein
explained that during the following years, Maximov also showed that
the idea of interaction between hemopoetic cells and their stroma
to be one of the most significant experiences. Monoclonal
antibodies, recombinant DNA technics and the improvement of tissue
culture models are the major developments to improve our
possibilities to clarify growth and differentiation functions of
hemopoetic cells. During the last two decades it was shown that
soluble products, released from T cells, were not only involved in
inducing B cells to produce specific immunoglobulin secretion after
antigen stimulation. Furthermore, lymphokines together with other
cytokines regulate the growth and differentiation of hemopoetic
cells. As I have learned from Dick Gershon, our knowledge of the
cellular basis for immunoregulation has come a long way since 450
B.C. Thucydides comments on the possible role of immune response in
controlling the Black Death. Dick Gershon speculated that no
scientific interest for these interesting observations was put
forth at that time. Perhaps the problems, the Athenians were having
with the Spartans, converted money from basis research into the
military budget.
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