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High specific activity is also required for isotopes meant to be
used for labeling hormones and other biological substances for
radioimmunoassays and other related assay procedures. Many imaging
and therapeutic applications are dependent on the use of
concentrated solution of radionuclides. Concentrated solutions of
radionuclide provide good labeling yield of molecules. With the
passage of time, the eluates obtained from radionuclide generator
systems yield low concentration of radionuclides, hence
concentration techniques will enhance the working life of
radionuclide generators. In this regard the concentration technique
developed in this study for Ga-68 will certainly increase the
purity of radionuclide as well as ensure the optimum use of
generator system in their working life time.
Technetium-99m is mostly eluted from 99Mo/99mTc generator system in
all nuclear medicine departments where radiopharmaceuticals are
prepared for gamma imaging purposes. The clinically useful lifetime
of a fission based 99Mo/99mTc generator is 2 weeks. At the end of
first working week, the radioactive concentration of the eluate is
about a quarter of that at the beginning of the week that places
limitations on the clinical procedures. These include
99mTc-sestamibi for myocardial perfusion studies and 99mTc-ECD
forbrain imaging. Hence safe procedure is needed for the
concentration of pertechnetate obtained from column chromatography
generators. The concentrated solution of pertechnetate obtained by
these methods were successfully employed for labeling of MIBI and
ECD kits.
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