This book constitutes the refereed proceedings of the 6th International Conference on Innovative Technologies and Learning, ICITL 2023, held in Porto, Portugal, during August 28–30, 2023.  The 64 full papers included in this book were carefully reviewed and selected from 147 submissions. They cover a wide range of many different research topics, such as: artificial intelligence in education; computational thinking in education; design and framework of learning systems; pedagogies to innovative technologies and learning; STEM/STEAM education; VR/AR/MR/XR in education; and application and design of innovative learning software.