In this book, the progress during the last ten years is reviewed and future plans outlined to realize and establish the concept of design in the biological sciences.

Design is a leading concept as well as the principal motivation for the creation of artificial systems. A successful design generally requires that the structures and functions of the elements that constitute the system as well as the principles that determine how the elements cooperate together to create function be fully understood. These requirements have not been satisfied within the fields of biotechnology and medicine. Compared to the recent emergence of artificial systems, living organisms acquired their present day structures and functions through evolution over three to four billion years. Despite the fact that the design of living organisms is recorded in the DNA sequence, our understanding of the structures and functions of the elements that constitute living organisms is very limited.

To fulfill the requirements, the following approaches were initiated under a ten-year project entitled "Biodesign Research." Firstly, we tried to isolate and characterize the functional elements that constitute the organelles of various organisms. Secondly, we tried to reconstitute systems that reproduce biological functions "in vitro" from individual elements in order to understand how the elements cooperate together to yield a function. Thirdly, we attempted to resolve biological structures at various resolutions ranging from the atomic to the cellular level to further our knowledge about the fundamental principles that various functions at the molecular level and to design artificial systems.

The Department of Defense's space acquisition enterprise has experienced numerous challenges since the advent of space power. Space borne capabilities are needed more than ever, but space acquisition frequently fails to meet its goals. The decades of space acquisition experience form a rich history that can be used to build a leading indicator of success to enable effective program execution. First, the space acquisition areas of greatest concern were determined to be cost, schedule and requirements. These areas are considered as systems composed of the people, processes and products that execute the program. Second, the vital interoperation characteristics, or attributes that each system must possess to be successful, can be extracted from past space acquisition lessons learned and placed into an interoperability maturity model.