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This two-volume book provides the first comprehensive survey of
opioid research, a field which has accumulated a tremendous amount
of literature since the identification of opioid receptors and
their endogenous ligands. In more than 60 chapters experts present
state-of-the-art reviews of this fascinating field, the topics
ranging from molecular biology to clinical applications. Part I
covers the multiplicity of opioid receptors, the chemistry of
opiates and opioid peptides as well as the neurophysiology of
opioids. Part II reviews a broad spectrum of physiological and
behavioral functions and pharmacological actions of opioids,
together with their neuroendocrinology, opioid tolerance and
dependence, concluding with pathophysiological aspects and clinical
use.
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