During recent years, major advances in surgical techniques, diagnostic methods, anesthesia and adjunctive treatment in the care of patients with subarachnoid hemorrhage have been achieved. Nevertheless, the overall outcome of patients with SAH cannot be regarded as satisfactory. The first part of the book concentrates on the pathogenetic mechanisms underlying vasospasm and edema, the principal causes of poor outcome. Recent progress in the field of membrane lipid metabolism has allowed the problem to be approached from an entirely new perspective. The possible participation of free radicals, membrane lipids and eicosanoids is thoroughly discussed. The second part features the problems of practical management of SAH patients. Timing and indication of surgery of aneurysms and the surgical techniques are described in detail.

This book constitutes the refereed proceedings of the 22nd International Symposium on Algorithms and Computation, ISAAC 2011, held in Yokohama, Japan in December 2011. The 76 revised full papers presented together with two invited talks were carefully reviewed and selected from 187 submissions for inclusion in the book. This volume contains topics such as approximation algorithms; computational geometry; computational biology; computational complexity; data structures; distributed systems; graph algorithms; graph drawing and information visualization; optimization; online and streaming algorithms; parallel and external memory algorithms; parameterized algorithms; game theory and internet algorithms; randomized algorithms; and string algorithms.

The abstracts and papers in this volume were presented at the Fifth Annual International Computing and Combinatorics Conference (COCOON '99), which was held in Tokyo, Japan from July 26 to 28, 1999. The topics cover most aspects of theoretical computer science and combinatorics pertaining to computing. In response to the call for papers, 88 high-quality extended abstracts were submitted internationally, of which 46 were selected for presentation by the p- gram committee. Every submitted paper was reviewed by at least three program committee members. Many of these papers represent reports on continuing - search, and it is expected that most of them will appear in a more polished and complete form in scienti c journals. In addition to the regular papers, this v- ume contains abstracts of two invited plenary talks by Prabhakar Raghavan and Seinosuke Toda. The conference also included a special talk by Kurt Mehlhorn on LEDA (Library of E cient Data types and Algorithms). The Hao Wang Award (inaugurated at COCOON '97) is given to honor the paper judged by the program committee to have the greatest scienti c merit. The recipients of the Hao Wang Award 1999 were Hiroshi Nagamochi and Tos- hide Ibaraki for their paper \An Approximation for Finding a Smallest 2-Edge- Connected Subgraph Containing a Speci ed Spanning Tree".