The term humanized mouse in this text refers to a mouse in which human tissues and cells have been transplanted and show the same biological function as they do in the human body. That is, the physiological properties and functions of tra- planted human tissues and cells can be analyzed in the mouse instead of using a living human body. It should therefore be possible to study the pathophysiology and treatment of human diseases in mice with good reproducibility. Thus, the hum- ized mouse can be used as a potent tool in both basic and clinical research in the future. The development of appropriate immunodeficient mice has been indispensable in the creation of the humanized mouse, which has been achieved through many years of efforts by several laboratories. The first stage on the road to the humanized mouse was the report on nude mice by Isaacson and Cattanach in 1962. Thereafter, nude mice were studied in detail by Falanagan and, in 1968, Pantelouris found that these mice have no thymus gland, which suggested that the mice lack transplan- tion immunity against xenografts such as human hematopoietic stem cells. At the Nude Mouse Workshops (organized by Regard, Povlsen, Nomura and colleagues) that were held nine times between 1972 and 1997, the possibility of creating a humanized mouse using nude mice was extensively examined. The results, however, showed that certain human cancers can be engrafted in nude mice, but unfortunately engraftment of normal human tissue was almost impossible.

The term humanized mouse in this text refers to a mouse in which human tissues and cells have been transplanted and show the same biological function as they do in the human body. That is, the physiological properties and functions of tra- planted human tissues and cells can be analyzed in the mouse instead of using a living human body. It should therefore be possible to study the pathophysiology and treatment of human diseases in mice with good reproducibility. Thus, the hum- ized mouse can be used as a potent tool in both basic and clinical research in the future. The development of appropriate immunodeficient mice has been indispensable in the creation of the humanized mouse, which has been achieved through many years of efforts by several laboratories. The first stage on the road to the humanized mouse was the report on nude mice by Isaacson and Cattanach in 1962. Thereafter, nude mice were studied in detail by Falanagan and, in 1968, Pantelouris found that these mice have no thymus gland, which suggested that the mice lack transplan- tion immunity against xenografts such as human hematopoietic stem cells. At the Nude Mouse Workshops (organized by Regard, Povlsen, Nomura and colleagues) that were held nine times between 1972 and 1997, the possibility of creating a humanized mouse using nude mice was extensively examined. The results, however, showed that certain human cancers can be engrafted in nude mice, but unfortunately engraftment of normal human tissue was almost impossible.

Telling stories: that sounds innocuous enough. But for the first chronicle in the Japanese vernacular, A Tale of Flowering Fortunes (Eiga monogatari), there was more to worry about than a good yarn. The health of the community was at stake. Flowering Tales is the first extensive literary study of this historical tale, which covers about 150 years of births, deaths, and happenings in late Heian society, a golden age of court literature in women's hands. Takeshi Watanabe contends that the blossoming of tales, marked by the Tale of Genji, inspired Eiga's new affective history: an exorcism of embittered spirits whose stories needed to be retold to ensure peace. Tracing the narrative arcs of politically marginalized figures, Watanabe shows how Eiga's female authors adapted the discourse and strategies of the Tale of Genji to rechannel wayward ghosts into the community through genealogies that relied not on blood but on literary resonances. These reverberations, highlighted through comparisons to contemporaneous accounts in courtiers' journals, echo through shared details of funerary practices, political life, and characterization. Flowering Tales reanimates these eleventh-century voices to trouble conceptions of history: how it ought to be recounted, who got to record it, and why remembering mattered.