This book constitutes the refereed proceedings of the 6th Annual Smart City 360 Degrees Summit. Due to COVID-19 pandemic the conference was held virtually. The volume combines selected papers of seven conferences, namely AISCOVID 2020 - International Conference on AI-assisted Solutions for COVID-19 and Biomedical Applications in Smart-Cities; EdgeIoT 2020 - International Conference on Intelligent Edge Processing in the IoT Era; IC4S 2020 - International Conference on Cognitive Computing and Cyber Physical Systems; CiCom 2020 - International Conference on Computational Intelligence and Communications; S-Cube 2020 - International Conference on Sensor Systems and Software; SmartGov 2020 - International Conference on Smart Governance for Sustainable Smart Cities; and finnally, the Urb-IOT 2020 -International Conference on IoT in Urban Space.