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This brief describes studies conducted by the authors on mid-size
drugs utilizing peptides and peptidomimetics, and on the
development of anti-HIV agents. Peptides are important biological
molecules and have various physiological actions. Peptide-based
drug discovery may help bring about the development of useful
medicines that are highly safe and show potent pharmacological
effects in small doses. Recently, it has been shown that there is
an important drug-like space in the mid-sized region between low-
and high-molecular-weight compounds. Thus, mid-size drugs such as
peptide compounds are being focused on. To date, several
peptidomimetics that mimic primary, secondary, and tertiary
structures of peptides have been developed to maintain and improve
biological activities and actions of peptides. In this book, the
features and advantages of mid-size drugs are described in detail.
In addition, the merits of utilizing peptidomimetics in the
development of mid-size drugs are referred to. Understanding such
peptide-derived mid-size drugs will lead to a comprehensive
expansion of medicinal chemistry.
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