This book presents the refereed proceedings of the 6th International Conference on Advanced Machine Learning Technologies and Applications (AMLTA 2021) held in Cairo, Egypt, during March 22-24, 2021, and organized by the Scientific Research Group of Egypt (SRGE). The papers cover current research Artificial Intelligence Against COVID-19, Internet of Things Healthcare Systems, Deep Learning Technology, Sentiment analysis, Cyber-Physical System, Health Informatics, Data Mining, Power and Control Systems, Business Intelligence, Social media, Control Design, and Smart Systems.