The Stein Fellow and Drexel University Pediatric Neuropsychology Symposium was held in collaboration with the Philadelphia Neuropsychology Society in November 2010. Pediatric Neuropsychology is a rapidly growing and dynamic subspecialty dealing with the normal and abnormal development of the human brain where new assessments and interventions and new professional issues are emerging. The Drexel Symposium brought together leading scientists and clinicians whose research, scholarship, and clinical practice are informing and shaping the evolution of the field. The goal of the Special Issue is to illustrate some of those research, clinical, and professional directions including advocacy and training that are specific to the developing subspecialty of Pediatric Neuropsychology.