This book constitutes the refereed proceedings of the 14th International Baltic Conference on Databases and Information Systems, DB&IS 2020, held in Tallinn, Estonia, in June 2020.* The 22 revised papers presented were carefully reviewed and selected from 52 submissions. The papers are centered around topics like architectures and quality of information systems, artificial intelligence in information systems, data and knowledge engineering, enterprise and information systems engineering, security of information systems. *The conference was held virtully due to the COVID-19 pandemic.