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The synthesis of chalcone system -C=C-C=O is relatively easy to
prepare, usually highly reactive and are starting point of
preparation of various bioactive compounds. This, -unsaturated
ketones (chalcones) can be synthesized by Claisen-Schmidt
condensation of different aromatic aldehydes with ketone and their
cyclization with hydrazine hydrate in basic condition. Numerous
pyrazoline derivatives have been found to possess considerable
biological activities, which stimulated the research activity in
this field. Amongst all the nitrogen containing five member
heterocycles, it have proved to be the most useful framework for
biological activities and have attracted attention of medicinal
chemists for both with regard to heterocyclic chemistry and the
pharmacological activities associated with them. We have
synhtesized some chalcones and pyrazolines and have studied their
antimicrobial activity.
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