This issue of Cardiology Clinics, edited by Jae K. Oh, William Miranda, and Terrence D. Welch, will cover a broad range of topics related to Pericardial Disease. Subjects discussed include, but are not limited to: Anatomy and Physiology of the Pericardium; Imaging of the Pericardium, Acute and Recurrent Pericarditis; Tuberculous and Infectious Pericarditis; Pericardial Involvement in Systemic Diseases / Special Forms; Cardiac Tamponade; Constrictive Pericarditis; Effusive-constrictive Pericarditis; Surgical Management; Percutaneous Therapy in Pericardial Diseases; Congenital Abnormalities of the Pericardium, and Neoplastic Pericardial Disease.