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Based on presentations by world-renowned investigators at the 72nd
annual Cold Spring Harbor Symposium on Quantitative Biology, this
volume reviews the latest advances in biological clocks and
rhythms. Topics include genetic and cellular studies aimed at
characterizing circadian mechanisms; systems approaches to
understanding physiological, endocrine, and neural networks; and
models used for studying mental and physical cycles. A variety of
normal and abnormal chronobiological patterns are discussed,
including sleep, aging, migration, hibernation, seasonality,
depression, and arrhythmias.
Based on presentations by world-renowned investigators at the 73rd
annual Cold Spring Harbor Symposium on Quantitative Biology, this
volume reviews the latest advances in research on the control and
regulation of stem cells. The topics covered include nuclear
reprogramming, regulation of stem cell self-renewal and
differentiation, the stem cell niche, and signaling and gene
regulation in stem cells. Studies of embryonic stem cells and adult
stem cells are covered, along with research shedding light on the
roles of these cells in regeneration and cancer.
Plants are integral to human wellbeing, and many species have been
domesticated for over ten thousand years. Evidence of plant
scientific investigation and classification can be found in ancient
texts from cultures around the world (Chinese, Indian, Greco-Roman,
Muslim etc.), while early modern botany can be traced to the late
15th and early 16th centuries in Europe. During the past several
decades plant biology has been revolutionized first by molecular
biology and then by the genomic era. The model organism Arabidopsis
thaliana has proved an invaluable tool for investigation into
fundamental processes in plant biology, many of which share
commonalities with animal biology. Plant-specific processes from
reproduction to immunity and second messengers have also yielded to
extensive investigation. With the genomes of more than thirty plant
species now available and many more planned in the near future, the
impact on our understanding of plant evolution and biology
continues to grow. Our increased ability to engineer plant species
to a variety of ends may provide novel solutions to ensure adequate
and reliable food production and renewable energy even as climate
change impacts our environment. The decision to focus the 2012
Symposium on plant science reflects the enormous research progress
achieved in recent years, and is intended to provide a broad
synthesis of the current state of the field, setting the stage for
future discoveries and application. This is the first Symposium in
this historic series focused exclusively on the botanical
sciences.
Plants are integral to human wellbeing, and many species have been
domesticated for over ten thousand years. Evidence of plant
scientific investigation and classification can be found in ancient
texts from cultures around the world (Chinese, Indian, Greco-Roman,
Muslim etc.), while early modern botany can be traced to the late
15th and early 16th centuries in Europe. During the past several
decades plant biology has been revolutionized first by molecular
biology and then by the genomic era. The model organism Arabidopsis
thaliana has proved an invaluable tool for investigation into
fundamental processes in plant biology, many of which share
commonalities with animal biology. Plant-specific processes from
reproduction to immunity and second messengers have also yielded to
extensive investigation. With the genomes of more than thirty plant
species now available and many more planned in the near future, the
impact on our understanding of plant evolution and biology
continues to grow. Our increased ability to engineer plant species
to a variety of ends may provide novel solutions to ensure adequate
and reliable food production and renewable energy even as climate
change impacts our environment. The decision to focus the 2012
Symposium on plant science reflects the enormous research progress
achieved in recent years, and is intended to provide a broad
synthesis of the current state of the field, setting the stage for
future discoveries and application. This is the first Symposium in
this historic series focused exclusively on the botanical sciences.
This volume is based on presentations by world-renowned
investigators who gathered at the 76th Cold Spring Harbor Symposium
on Quantitative Biology. It reviews the latest advances in our
understanding of metabolism and disease, including research on fat,
exercise and rhythms; insulin resistance and sensitivity; lifespan,
aging and cancer; regulation and dysregulation of metabolism;
signaling and gene regulation; environment and sensing; metabolic
reprogramming; clocks and intermediary metabolism; metabolism and
cancer; and autophagy, timing and small RNAs.
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