In this second edition, the authors present a thorough, advanced review of the interactions between motoneurones and muscles in vertebrates. The book discusses the significance of nerve-muscle interactions for the normal development and maintenance of the vertebrate neuromuscular system and reviews the consequences of their disruption. The plasticity of nerve-muscle interactions and the potential for repair is analyzed, as is the importance of neuromuscular activity in development. The subject is approached from a broad viewpoint and the authors integrate results from many disciplines to illustrate the significance of neuromuscular interaction for normal locomotor activity. This approach makes the book useful for clinical researchers of neuromuscular disease.