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The International Life Sciences Institute (ILSI) was estab lished
in 1978 to stimulate and support scientific research and
educational programs related to nutrition, toxicology, and food
safety, and to encourage cooperation in these programs among
scientists in universities, industry, and government agencies to
assist in the resolution of health and safety issues. To supplement
and enhance these efforts, ILSI has made a major commitment to
supporting programs to harmon ize toxicological testing, to advance
a more uniform inter pretation of bioassay results worldwide, to
promote a common understanding of lesion classifications, and to
encourage wide discussion of these topics among scien tists. The
Monographs on the Pathology of Laboratory Ani mals are designed to
facilitate communication among those involved in the safety testing
of foods, drugs, and chemicals. The complete set will cover all
organ systems and is intended for use by pathologists,
toxicologists, and others concerned with evaluating toxicity and
carcinogen icity studies. The international nature of the project -
as reflected in the composition of the editorial board and the
diversity of the authors and editors - strengthens our ex
pectations that understanding and cooperation will be im proved
worldwide through the series. Alex Malaspina President
International Life Sciences Institute Preface This book, on the
nervous system, is the sixth volume of a set pre pared under the
sponsorship of the International Life Sciences Insti tute (ILSI)."
The International Life Sciences Institute (ILSI) was creat ed to
promote cooperative efforts toward solving critical health and
safety questions involving foods, drugs, cosmet ics, chemicals, and
other aspects of the environment. The Officers and Trustees believe
that questions regarding health and safety are best resolved when
government and industry rely on scientific investigations,
analyses, and reviews by independent experts. Further, the
scientific aspects of an issue should be examined and discussed on
an international basis, separate from the political concerns of
individual companies. ILSI is pleased to sponsor this set of
monographs on the pathology of laboratory animals. This project
will be use ful in improving the scientific basis for the
application of pathologic techniques to health and safety
evaluation of substances in our environment. The world wide
distribu tion of the authors, editors, and Editorial Board who are
creating these monographs strengthens the expectation that
international communication and cooperation will al so be
strengthened."
The International Life Sciences Institute (ILSI) was estab lished
to stimulate and support scientific research and edu cational
programs in nutrition, toxicology, and food safe ty; and to
encourage cooperation in these programs among scientists from
universities, industry, and government in order to facilitate the
resolution of health and safety issues. The officers and trustees
of ILSI believe that questions re garding health and safety are
best resolved when govern ment and industry rely on scientific
investigations, analy ses, and reviews by independent experts. This
process is furthered by the examination and discussion of issues on
an international basis. ILSI is pleased to sponsor this set of
monographs on the pathology of laboratory animals. This project
collectively brings together the most comprehensive information on
non-neoplastic and neoplastic lesions that occur in com monly used
laboratory animals. The international compo sition of the authors,
editors, and editorial board who have contributed to these
monographs strengthens our expecta tions that understanding and
cooperation will be strength ened worldwide through this series."
This publication is a personal account of experiences in the
world of science, medicine, public health, drug development, and
international health care, obtained from many different areas of
the world during the rewarding and diverse fifty-year career of
Thomas Jones, MD. That career has included major activities in the
United States, Switzerland, the Philippines, Thailand, and Brazil,
as well as smaller experiences in virtually every corner of the
globe. It has included work in universities, the corporate world of
drug research, and work with government organizations.
There have been misdirections in health care that have been
partially overlooked, perhaps because of attention given to the
numerous--primarily technical--advances that have been made. The
essays, in spite of their rather negative message, are intended to
be a pleasure to read--coherent, logical, tasteful, and accurate,
with humor where appropriate but severity where needed.
The essays have been divided into three types: first, those that
are relevant to social, governmental, and drug policy issues in our
society; second, those relevant to special approaches to health
care from the viewpoint of a specialist in infectious diseases; and
third, those regarding specific infectious diseases. These three
areas overlap at numerous points, but they allow the reader to
direct his or her attention to policy issues, health care
approaches, or the specific disease.
This publication is a personal account of experiences in the
world of science, medicine, public health, drug development, and
international health care, obtained from many different areas of
the world during the rewarding and diverse fifty-year career of
Thomas Jones, MD. That career has included major activities in the
United States, Switzerland, the Philippines, Thailand, and Brazil,
as well as smaller experiences in virtually every corner of the
globe. It has included work in universities, the corporate world of
drug research, and work with government organizations.
There have been misdirections in health care that have been
partially overlooked, perhaps because of attention given to the
numerous--primarily technical--advances that have been made. The
essays, in spite of their rather negative message, are intended to
be a pleasure to read--coherent, logical, tasteful, and accurate,
with humor where appropriate but severity where needed.
The essays have been divided into three types: first, those that
are relevant to social, governmental, and drug policy issues in our
society; second, those relevant to special approaches to health
care from the viewpoint of a specialist in infectious diseases; and
third, those regarding specific infectious diseases. These three
areas overlap at numerous points, but they allow the reader to
direct his or her attention to policy issues, health care
approaches, or the specific disease.
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