JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.

JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.

Interim Manager formen mittlerweile zunehmend einen Archetypus atypischer Beschaftigung. Die Paradigmen der modernen Arbeitswelt gehen auch an qualifizierten Managern nicht spurlos vorbei. Unternehmen lagern inzwischen sogar Management-Aufgaben aus. Ist ein Interim Manager also lediglich die "Umkehrung" eines angestellten Managers? Oder gibt es Besonderheiten, die nicht ohne weiteres aus der Angestellten-Perspektive zu betrachten sind? Der Autor beleuchtet das Phanomen Interim Management aus dem Blickwinkel eines Interim Managers. Dazu wahlt er als Ausgangspunkt die drei Dimensionen Ressourcen, Wettbewerb und Variable Vergutung. In zahlreichen Experteninterviews werden Informationen daruber gesammelt, wie Interim Manager ihr instabiles Geschaftsmodell langfristig erfolgreicher gestalten koennen. Daruber hinaus bietet das Buch anwendungsorientierte Instrumente, die von selbstandigen und angestellten Managern gleichermassen als Quelle eines Self-Profiling genutzt werden koennen.

Title: The Virgin Martir, a Tragedie in five acts and in verse and prose.]Publisher: British Library, Historical Print EditionsThe British Library is the national library of the United Kingdom. It is one of the world's largest research libraries holding over 150 million items in all known languages and formats: books, journals, newspapers, sound recordings, patents, maps, stamps, prints and much more. Its collections include around 14 million books, along with substantial additional collections of manuscripts and historical items dating back as far as 300 BC.The POETRY & DRAMA collection includes books from the British Library digitised by Microsoft. The books reflect the complex and changing role of literature in society, ranging from Bardic poetry to Victorian verse. Containing many classic works from important dramatists and poets, this collection has something for every lover of the stage and verse. ++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++ British Library Massinger, Philip; Dekker, Thomas; 1661. 4 . Ashley1112.

Title: The Virgin Martir, a Tragedie in five acts and in verse and prose.]Publisher: British Library, Historical Print EditionsThe British Library is the national library of the United Kingdom. It is one of the world's largest research libraries holding over 150 million items in all known languages and formats: books, journals, newspapers, sound recordings, patents, maps, stamps, prints and much more. Its collections include around 14 million books, along with substantial additional collections of manuscripts and historical items dating back as far as 300 BC.The POETRY & DRAMA collection includes books from the British Library digitised by Microsoft. The books reflect the complex and changing role of literature in society, ranging from Bardic poetry to Victorian verse. Containing many classic works from important dramatists and poets, this collection has something for every lover of the stage and verse. ++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++ British Library Massinger, Philip; Dekker, Thomas; 1651. 4 . 644.f.3.

Title: The Virgin Martir, a Tragedie in five acts and in verse and prose.]Publisher: British Library, Historical Print EditionsThe British Library is the national library of the United Kingdom. It is one of the world's largest research libraries holding over 150 million items in all known languages and formats: books, journals, newspapers, sound recordings, patents, maps, stamps, prints and much more. Its collections include around 14 million books, along with substantial additional collections of manuscripts and historical items dating back as far as 300 BC.The POETRY & DRAMA collection includes books from the British Library digitised by Microsoft. The books reflect the complex and changing role of literature in society, ranging from Bardic poetry to Victorian verse. Containing many classic works from important dramatists and poets, this collection has something for every lover of the stage and verse. ++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++ British Library Massinger, Philip; Dekker, Thomas; Decker, Thomas; 1661. 4 . Ashley1112.

This scarce antiquarian book is a selection from Kessinger Publishing's Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone

The authors provide a simplified version of the theory of Sensory Integration with practical applications for both the lay person and practicing professionals. This book can serve as a quick reference guide for parents of children with sensory processing difficulties and for the general population for recognizing their own and others sensory processing styles throughout the lifespan.