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Research in diabetes has accelerated in two areas, both of which
are being reviewed in CTMI. The first is the use of a variety of
animal models; the second is basic research in human investigation,
islet cell antigens, and mapping of genes as sociated with
susceptibility to disease. Dr. Thomas Dyrberg accepted editorial
responsibility for this volume, which covers the first area. A
second book, to be published later in the year, is edited by Drs.
Brekkeskov and Hansen (CTMI 164, see page VI for contents).
Although the contributors to both volumes represent the
international scientific community, the editors are from the
Hagedorn Research Laboratory in Denmark. Work at this institute and
the Steno Memorial Hospital has been dedicated to research in
diabetes for decades, and the insti tutions were appointed WHO
Collaborating Centres for Re search and Training on the
Pathogenesis of Diabetes Mellitus in 1983. It is worth noting that
while addressing the hypothesis of the role of class II major
histocompatibility glycoproteins in autoimmune diabetes
(insulin-dependent diabetes, IDDM) a number of investigators
established animal models in which class II molecules were
expressed under the control of the rat insulin promoter. While
generating interesting information on 100M, the finding of
immunologic tolerance in such transgenic mice has attracted the
attention of several basic immunologic laboratories for quite
different reasons. Thus, we are reminded again of the Pasteur
dictum that "chance favors the prepared mind. " Michael B. A.
Oldstone, M. D."
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