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This critical review volume explores the theme of ABC transporters
in the context of basic cancer research and its role in
drug-resistant tumors. The chapters provided complement basic
research by including investigations from translational
applications to clinical oncology. The development of resistance is
a major obstacle in cancer chemotherapy and the field has been
moving rapidly in terms of determining the mechanisms for blocking
ABC transporter-mediated drug efflux by specific inhibitors and
thereby overcoming multidrug resistance. The volume covers these
issues in careful detail. Additional topics include the relevance
of ABC transporters in resistance to novel and established
anticancer drugs and prognosis of patients to compounds, compounds
used in photodynamic therapy, tyrosine kinase inhibitors and
others. Furthermore, the potential of radiopharmaceuticals for
diagnosis of multidrug-resistant tumors and of nanotechnology to
combat drug-resistant tumors is also discussed.
This critical review volume explores the theme of ABC transporters
in the context of basic cancer research and its role in
drug-resistant tumors. The chapters provided complement basic
research by including investigations from translational
applications to clinical oncology. The development of resistance is
a major obstacle in cancer chemotherapy and the field has been
moving rapidly in terms of determining the mechanisms for blocking
ABC transporter-mediated drug efflux by specific inhibitors and
thereby overcoming multidrug resistance. The volume covers these
issues in careful detail. Additional topics include the relevance
of ABC transporters in resistance to novel and established
anticancer drugs and prognosis of patients to compounds, compounds
used in photodynamic therapy, tyrosine kinase inhibitors and
others. Furthermore, the potential of radiopharmaceuticals for
diagnosis of multidrug-resistant tumors and of nanotechnology to
combat drug-resistant tumors is also discussed.
Wie wirkt ein Medikament oder ein Gift in der Zelle? Thomas
Efferth spannt einen Bogen von den allgemeinen Grundlagen der
Pharmakologie und Toxikologie zu den molekularen Wirkmechanismen
der wichtigsten Medikamente und Gifte. Aktuelle Themen wie
Gentherapie, Immuntherapie und Stammzelltherapie behandelt er
ebenso wie Pharmakogenetik und -genomik oder systembiologische
Ansatze in Pharmakologie und Toxikologie. Die molekulare
Pharmakologie und Toxikologie ist ein sich rasch entwickelndes
Gebiet. Dieses Buch gibt Studenten einen fundierten Uberblick uber
den aktuellen Wissensstand und einen verstandlichen Einblick in
moderne Forschungskonzepte."
This book is the first of its kind in bringing together
biodiversity, chemical ecology, phytochemistry and cancer therapy.
The highlight of the book is an exhaustive compilation of
scientific data on biodiversity of medicinal plants, biodiversity
and metagenomics, chemical ecology of medicinal plants, chemical
ecology of marine organisms, natural products from terrestrial
microbial organisms with activity towards cancer cells, marine
organisms, ethnopharmacology and phytotherapy, contribution of
African flora in world fight against cancer, natural products
derived from terrestrial plants with activity towards cancer cells
and established anticancer drugs from natural origin.The book
discusses the state-of-the-art of each topic to serve as reference
resource tools for graduate students as well as scientists and
scholars in pharmaceutical sciences, pharmacology, organic
chemistry and biochemistry, pharmacognosy, phytochemistry,
ethnomedicine and ethnopharmacology, complementary and alternative
medicine, medical and public health sciences and others. It
includes cutting-edge developments in anticancer discovery from
both medicinal plants and organisms.
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