This volume covers some of the topics that are related to the rapidly growing field of biomedical informatics. In June 11-12, 2010 a workshop entitled 'Optimization and Data Analysis in Biomedical Informatics' was organized at The Fields Institute. Following this event invited contributions were gathered based on the talks presented at the workshop, and additional invited chapters were chosen from world's leading experts. In this publication, the authors share their expertise in the form of state-of-the-art research and review chapters, bringing together researchers from different disciplines and emphasizing the value of mathematical methods in the areas of clinical sciences. This work is targeted to applied mathematicians, computer scientists, industrial engineers, and clinical scientists who are interested in exploring emerging and fascinating interdisciplinary topics of research. It is designed to further stimulate and enhance fruitful collaborations between scientists from different disciplines.

With contributions by specialists in optimization and practitioners in the fields of aerospace engineering, chemical engineering, and fluid and solid mechanics, the major themes include an assessment of the state of the art in optimization algorithms as well as challenging applications in design and control, in the areas of process engineering and systems with partial differential equation models.

With contributions by specialists in optimization and practitioners in the fields of aerospace engineering, chemical engineering, and fluid and solid mechanics, the major themes include an assessment of the state of the art in optimization algorithms as well as challenging applications in design and control, in the areas of process engineering and systems with partial differential equation models.

This volume covers some of the topics that are related to the rapidly growing field of biomedical informatics. In June 11-12, 2010 a workshop entitled 'Optimization and Data Analysis in Biomedical Informatics' was organized at The Fields Institute. Following this event invited contributions were gathered based on the talks presented at the workshop, and additional invited chapters were chosen from world's leading experts. In this publication, the authors share their expertise in the form of state-of-the-art research and review chapters, bringing together researchers from different disciplines and emphasizing the value of mathematical methods in the areas of clinical sciences. This work is targeted to applied mathematicians, computer scientists, industrial engineers, and clinical scientists who are interested in exploring emerging and fascinating interdisciplinary topics of research. It is designed to further stimulate and enhance fruitful collaborations between scientists from different disciplines.

With contributions by specialists in optimization and practitioners in the fields of aerospace engineering, chemical engineering, and fluid and solid mechanics, the major themes include an assessment of the state of the art in optimization algorithms as well as challenging applications in design and control, in the areas of process engineering and systems with partial differential equation models.

Inverse problems and optimal design have come of age as a consequence of the availability of better, more accurate, and more efficient simulation packages. Many of these simulators, which can run on small workstations, can capture the complicated behavior of the physical systems they are modeling, and have become commonplace tools in engineering and science. There is a great desire to use them as part of a process by which measured field data are analyzed or by which design of a product is automated. A major obstacle in doing precisely this is that one is ultimately confronted with a large-scale optimization problem. This volume contains expository articles on both inverse problems and design problems formulated as optimization. Each paper describes the physical problem in some detail and is meant to be accessible to researchers in optimization as well as those who work in applied areas where optimization is a key tool. What emerges in the presentations is that there are features about the problem that must be taken into account in posing the objective function, and in choosing an optimization strategy. In particular there are certain structures peculiar to the problems that deserve special treatment, and there is ample opportunity for parallel computation. THIS IS BACK COVER TEXT Inverse problems and optimal design have come of age as a consequence of the availability of better, more accurate, and more efficient, simulation packages. The problem of determining the parameters of a physical system from

The calculation of partial derivatives is a fundamental need in scientific computing. Automatic differentiation (AD) can be applied straightforwardly to obtain all necessary partial derivatives (usually first and, possibly, second derivatives) regardless of a code's complexity. However, the space and time efficiency of AD can be dramatically improved - sometimes transforming a problem from intractable to highly feasible - if inherent problem structure is used to apply AD in a judicious manner. This book discusses the efficient use of AD to solve real problems, especially multidimensional zero-finding and optimization, in the MATLAB environment. This book is concerned with the determination of the first and second derivatives in the context of solving scientific computing problems with an emphasis on optimization and solutions to nonlinear systems. The authors focus on the application rather than the implementation of AD, solve real nonlinear problems with high performance by exploiting the problem structure in the application of AD, and provide many easy to understand applications, examples, and MATLAB templates.