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Cellular Biophysics is a quantitatively oriented basic physiology
text for senior undergraduate and graduate students in
bioengineering, biophysics, physiology, and neuroscience programs.
It will also serve as a major reference work for biophysicists.
Developed from the author's notes for a course that he has taught
at MIT for many years, these books provide a clear and logical
explanation of the foundations of cell biophysics, teaching
transport and the electrical properties of cells from a combined
biological, physical, and engineering viewpoint. Each volume
contains introductory chapters that motivate the material and
present it in a broad historical context. Important experimental
results and methods are described. Theories are derived almost
always from first principles so that students develop an
understanding of not only the predictions of the theory but also
its limitations. Theoretical results are compared carefully with
experimental findings and new results appear throughout. There are
many time-tested exercises and problems as well as extensive lists
of references. The volume on transport is unique in that no other
text on this important topic develops it clearly and systematically
at the student level. It explains all the principal mechanisms by
which matter is transported across cellular membranes and describes
the homeostatic mechanisms that allow cells to maintain their
concentrations of solutes, their volume, and the potential across
the membrane. Chapters are organized by individual transport
mechanisms-diffusion, osmosis, coupled solute and solvent
transport, carrier-mediated transport, and ion transport (both
passive and active). A final chapter discusses the interplay of all
these mechanisms in cellular homeostasis.
Cellular Biophysics is a quantitatively oriented basic physiology
text for senior undergraduate and graduate students in
bioengineering, biophysics, physiology, and neuroscience programs.
It will also serve as a major reference work for
biophysicists.Developed from the author's notes for a course that
he has taught at MIT for many years, these books provide a clear
and logical explanation of the foundations of cell biophysics,
teaching transport and the electrical properties of cells from a
combined biological, physical, and engineering viewpoint. Each
volume contains introductory chapters that motivate the material
and present it in a broad historical context. Important
experimental results and methods are described. Theories are
derived almost always from first principles so that students
develop an understanding of not only the predictions of the theory
but also its limitations. Theoretical results are compared
carefully with experimental findings and new results appear
throughout. There are many time-tested exercises and problems as
well as extensive lists of references. The volume on the electrical
properties of cells covers both electrically inexcitable cells as
well as electrically excitable cells such as neurons and muscle
cells. Included are chapters on lumped-parameter and
distributed-parameter models of cells, linear electric properties
of cells, the Hodgkin-Huxley model of the giant axon of the squid,
saltatory conduction in myelinated nerve fibers, and voltage-gated
ion channels.
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