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This is the first book in the series to focus on dynamic
hyperpolarized nuclear magnetic resonance, a burgeoning topic in
biophysics. The volume follows the format and style of the Handbook
of Modern Biophysics series and expands on topics already discussed
in previous volumes. It builds a theoretical and experimental
framework for students and researchers who wish to investigate the
biophysics and biomedical application of dynamic hyperpolarized
NMR. All contributors are internationally recognized experts, lead
the dynamic hyperpolarized NMR field, and have first-hand knowledge
of the chapter material. The book covers the following topics:
Hyperpolarization by dissolution Dynamic Nuclear Polarization
Design considerations for implementing a hyperpolarizer Chemical
Shift Imaging with Dynamic Hyperpolarized NMR Signal Sampling
Strategies in Dynamic Hyperpolarized NMR Kinetic Modeling of
Enzymatic Reactions in Analyzing Hyperpolarized NMR Data Using
Hyperpolarized NMR to Understand Biochemistry from Cells to Humans
Innovating Metabolic Biomarkers for Hyperpolarized NMR New Insights
into Metabolic Regulation from Hyperpolarized 13C MRS/MRI Studies
Novel Views on Heart Function from Dynamic Hyperpolarized NMR
Insights on Lactate Metabolism in Skeletal Muscle based on 13C
Dynamic Nuclear Polarization Studies About the Editors Dirk Mayer
is Professor of Diagnostic Radiology and Nuclear Medicine at the
University of Maryland and is the Director of Metabolic Imaging. He
is a recognized expert on dynamic nuclear polarization (DNP)
MRI-based imaging techniques and has optimized acquisition and
reconstruction techniques, has constructed kinetic modeling for
quantitative analysis, and has developing new probes. Thomas Jue is
Professor of Biochemistry and Molecular Medicine at the University
of California Davis. He is an internationally recognized expert in
developing and applying magnetic resonance techniques to study
animal as well as human physiology in vivo. He served as a Chair of
the Biophysics Graduate Group Program at UC Davis, where he started
to redesign a graduate curriculum that balances physical
science/mathematics formalism and biomedical perspective in order
to promote interest at the interface of physical science,
engineering, mathematics, biology, and medicine. The Handbook of
Modern Biophysics represents an aspect of that effort.
Handbook of Modern Biophysics brings current biophysics topics into
focus, so that biology, medical, engineering, mathematics, and
physical-science students or researchers can learn fundamental
concepts and the application of new techniques in addressing
biomedical challenges. Chapters will develop the conceptual
framework of the physics formalism and illustrate the biomedical
applications. With the addition of problem sets, guides to further
study, and references, the interested reader can continue to
independently explore the ideas presented.Volume 5: Modern Tools of
BiophysicsEditor: Thomas Jue, PhDIn Modern Tools of Biophysics, a
group of prominent professors have provided insights into the tools
used in biophysics with respect to the following topics: Wave
Theory of Image Formation in a Microscope: Basic Theory and
Experiments Computer Simulations and Nonlinear Dynamics of Cardiac
Action Potentials Myoglobin and Hemoglobin Contribution to the NIRS
Signal in Muscle Anomalous Low Angle X-Ray Scattering of Membrane
with Lanthanides Recording of Ionic Currents under Physiological
Conditions-Action Potential-Clamping and "Onion-Peeling" Techniques
Patch Clamp Technique and Applications About the EditorThomas Jue
is a Professor in the Department of Biochemistry and Molecular
Medicine at the University of California, Davis. He is an
internationally recognized expert in developing and applying
magnetic resonance techniques to study animal as well as human
physiology in vivo and has published extensively in the field of
magnetic resonance spectroscopy and imaging, near-infrared
spectroscopy, bioenergetics, cardiovascular regulation, exercise,
and marine biology. He served as a Chair of the Biophysics Graduate
Group Program at UC Davis, where he started to develop scholarly
approaches to educate graduate students with a balance of
physical-science/mathematics formalism and biomedical perspective
in order to promote interest at the interface of physical science,
engineering, mathematics, biology, and medicine. He continues to
develop the biophysics curriculum, and the Handbook of Modern
Biophysics represents an aspect of that effort.
Handbook of Modern Biophysics brings current biophysics topics into
focus, so that biology, medical, engineering, mathematics, and
physical-science students or researchers can learn fundamental
concepts and the application of new techniques in addressing
biomedical challenges. Chapters will develop the conceptual
framework of the physics formalism and illustrate the biomedical
applications. With the addition of problem sets, guides to further
study, and references, the interested reader can continue to
independently explore the ideas presented.Volume 5: Modern Tools of
BiophysicsEditor: Thomas Jue, PhDIn Modern Tools of Biophysics, a
group of prominent professors have provided insights into the tools
used in biophysics with respect to the following topics: Wave
Theory of Image Formation in a Microscope: Basic Theory and
Experiments Computer Simulations and Nonlinear Dynamics of Cardiac
Action Potentials Myoglobin and Hemoglobin Contribution to the NIRS
Signal in Muscle Anomalous Low Angle X-Ray Scattering of Membrane
with Lanthanides Recording of Ionic Currents under Physiological
Conditions-Action Potential-Clamping and "Onion-Peeling" Techniques
Patch Clamp Technique and Applications About the EditorThomas Jue
is a Professor in the Department of Biochemistry and Molecular
Medicine at the University of California, Davis. He is an
internationally recognized expert in developing and applying
magnetic resonance techniques to study animal as well as human
physiology in vivo and has published extensively in the field of
magnetic resonance spectroscopy and imaging, near-infrared
spectroscopy, bioenergetics, cardiovascular regulation, exercise,
and marine biology. He served as a Chair of the Biophysics Graduate
Group Program at UC Davis, where he started to develop scholarly
approaches to educate graduate students with a balance of
physical-science/mathematics formalism and biomedical perspective
in order to promote interest at the interface of physical science,
engineering, mathematics, biology, and medicine. He continues to
develop the biophysics curriculum, and the Handbook of Modern
Biophysics represents an aspect of that effort.
In keeping with the style of the Handbook of Modern Biophysics,
this fourth volume, Application of Near-Infrared Spectroscopy in
Biomedicine, balances the need for physical science/mathematics
formalism with a demand for biomedical perspectives. Each chapter
divides the presentation into two major parts: the first
establishes the conceptual framework and describes the
instrumentation or technique, while the second illustrates current
applications in addressing complex biology questions. With the
additional sections on further reading, problems, and references,
the interested reader can explore some chapter ideas more widely.
In keeping with goal and style of the Handbook in Modern Biophysics
series, the proposed book will maintain a chapter structure that
contains two parts: concepts and biological application. The book
also integrates all the chapters into a smooth, continuous
discourse. The first and second chapters establish the mathematical
methods and theoretical framework underpinning the different topics
in the rest if the book. Other chapters will use the theoretical
framework as a basis to discuss optical and NMR approaches. Each
chapter will contain innovative didactic elements that facilitate
teaching, self-study, and research preparation (key points,
summary, exercise, references).
In keeping with the style of the Handbook of Modern Biophysics,
this fourth volume, Application of Near-Infrared Spectroscopy in
Biomedicine, balances the need for physical science/mathematics
formalism with a demand for biomedical perspectives. Each chapter
divides the presentation into two major parts: the first
establishes the conceptual framework and describes the
instrumentation or technique, while the second illustrates current
applications in addressing complex biology questions. With the
additional sections on further reading, problems, and references,
the interested reader can explore some chapter ideas more widely.
The book, Biomembrane Frontiers: Nanostructures, Models, and the
Design of Life, a volume in the Handbook of Modern Biophysics
series, is based on a workshop held on the 20th and 21st of March
2008 at the University of California Davis. Unlike other meeting
monographs, the book presents the exciting frontiers of biomembrane
research for both expert and student c- leagues interested in
research at the interface of biology and physics. The idea of the
workshop originated from discussions about how to create an
effective o- reach for the NSF-NIRT joint project "Aerogel and
Nanoporous Materials for Biomolecular Applications" between the
Longo, Faller, and Risbud groups at UC Davis and the groups of Curt
Frank at Stanford and Joe Satcher at Lawrence Livermore National
Laboratory. In the p- ject we interacted with researchers from
diverse backgrounds and hoped to create an oppor- nity to foster a
multi- and interdisciplinary exchange of ideas. Thus, the workshop
idea was c- ceived. The workshop brought together experts working
on many different aspects of biological membranes: from theory and
simulation, to supported model bilayers, and to clinical appli-
tions. Several material scientists working on the interactions of
biological membranes with b- logical or nonbiological materials
also participated. Such a diverse set of experts in one meeting is
unusual, as the different communities of theorists and
experimentalists working on model membranes and real biological
systems are typically quite distinct and do not often interact.
In keeping with goal and style of the Handbook in Modern
Biophysics series, the proposed book will maintain a chapter
structure that contains two parts: concepts and biological
application. The book also integrates all the chapters into a
smooth, continuous discourse. The first and second chapters
establish the mathematical methods and theoretical framework
underpinning the different topics in the rest if the book. Other
chapters will use the theoretical framework as a basis to discuss
optical and NMR approaches. Each chapter will contain innovative
didactic elements that facilitate teaching, self-study, and
research preparation (key points, summary, exercise,
references).
NMR in Biomedicine takes a unique didactic approach to present
magnetic resonance, starting from basic principles and concluding
with leading spectroscopic and imaging applications used in
biomedical research. The expert authors focus on the essential
physical principles that all advanced students and practitioners
must master. The book includes chapters on susceptibility,
resonance, chemical shift, spin-spin coupling, relaxation, chemical
exchange and decoupling.
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