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Studies on Retinal and Choroidal Disorders examines the role that
oxidative and nitrosative stress plays in the complex physiology
and pathophysiology of the retina and choroid. Both the basic
science researcher and the clinical practitioner can use this book
as a guide to the current understanding of retinal and choroidal
cellular mechanisms involved in aging and disease. Beginning with a
review of oxidative stress and inflammation in the pathoetiology of
AMD and a review of the complement system in the retina, the book
then takes a detailed look at oxidative stress in lipid metabolism
and oxidized lipoproteins in the retina. It examines the
anti-apoptotic activity of -crystallins in the presence of
glutathione, oxidative stress in the mitochondria and endoplasmic
reticulum, the role of iron in retinal disease, the mechanisms of
pathological VEGF expression, NAPDH oxidase mechanisms, and
Hepatocyte Growth Factor in oxidative stress in the retina. A
detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows.
Then a detailed examination of the systemic changes in AMD is
followed by a discussion of cerium oxide nanoparticle reduction of
oxidative stress. Two chapters discuss progenitor cells in the
cause and treatment of retinal diseases including AMD and diabetic
retinopathy. Natural compounds in the prevention and treatment of
retinal diseases are exhaustively presented, followed by a chapter
on serotonin 5-HT1A receptor agonists in oxidative stress of the
retina. The current anti-VEGF treatment strategies of neovascular
AMD are then given. The volume continues with a detailed look at
nitric oxide and inducible nitric oxide synthase in retinal
vascular disease, an explanation of an in vivo technique of
studying the effect of lipid hydroperoxides on circulating
leucocytes in the retina, an excellent review of oxidative stress
in retinopathy of prematurity, and a look at VEGF induced oxidative
stress in the retinal ganglion cell. The book ends with a detail
examination of the role of carotenoids in retinal health and
disease. These 31 chapters summarize what is known about oxidative
stress in retinal and choroidal disorders. All those involved with
degenerative diseases of the eye will find Studies on Retinal and
Choroidal Disorders to be illuminating and comprehensive.
Studies on Retinal and Choroidal Disorders examines the role that
oxidative and nitrosative stress plays in the complex physiology
and pathophysiology of the retina and choroid. Both the basic
science researcher and the clinical practitioner can use this book
as a guide to the current understanding of retinal and choroidal
cellular mechanisms involved in aging and disease. Beginning with a
review of oxidative stress and inflammation in the pathoetiology of
AMD and a review of the complement system in the retina, the book
then takes a detailed look at oxidative stress in lipid metabolism
and oxidized lipoproteins in the retina. It examines the
anti-apoptotic activity of -crystallins in the presence of
glutathione, oxidative stress in the mitochondria and endoplasmic
reticulum, the role of iron in retinal disease, the mechanisms of
pathological VEGF expression, NAPDH oxidase mechanisms, and
Hepatocyte Growth Factor in oxidative stress in the retina. A
detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows.
Then a detailed examination of the systemic changes in AMD is
followed by a discussion of cerium oxide nanoparticle reduction of
oxidative stress. Two chapters discuss progenitor cells in the
cause and treatment of retinal diseases including AMD and diabetic
retinopathy. Natural compounds in the prevention and treatment of
retinal diseases are exhaustively presented, followed by a chapter
on serotonin 5-HT1A receptor agonists in oxidative stress of the
retina. The current anti-VEGF treatment strategies of neovascular
AMD are then given. The volume continues with a detailed look at
nitric oxide and inducible nitric oxide synthase in retinal
vascular disease, an explanation of an in vivo technique of
studying the effect of lipid hydroperoxides on circulating
leucocytes in the retina, an excellent review of oxidative stress
in retinopathy of prematurity, and a look at VEGF induced oxidative
stress in the retinal ganglion cell. The book ends with a detail
examination of the role of carotenoids in retinal health and
disease. These 31 chapters summarize what is known about oxidative
stress in retinal and choroidal disorders. All those involved with
degenerative diseases of the eye will find Studies on Retinal and
Choroidal Disorders to be illuminating and comprehensive.
An exciting contribution to the field, Visual Dysfunction in
Diabetes: The Science of Patient Impairment and Improvement is
designed with two overriding objectives: to help readers understand
the impact of vision impairment in people living daily with
diabetes rather than considering diabetic retinopathy solely as a
medical problem, and to explore what we know and don't know about
the ways diabetes affect the eye. With the plethora of new
information being generated, there are still a series of
fundamental questions that must be addressed if effective
treatments for diabetic retinopathy are to be found and applied.
Developed by a renowned group of authorities, Visual Dysfunction in
Diabetes: The Science of Patient Impairment and Improvement offers
responses and context for a range of questions, such as: do
metabolic factors beyond glucose contribute to vision-threatening
diabetic retinopathy? If so, how do these lead to vision
impairment? Is diabetic retinopathy a response to systemic
metabolic abnormalities or are there unique ocular problems related
to insulin resistance? What is the relationship between the neural,
vascular, and inflammatory abnormalities in diabetic retinopathy?
Do they represent a pathological cascade induced sequentially or
simultaneous responses to one or more metabolic perturbations? The
authors note that if we do not address these types of questions, it
is possible that the long process of developing new therapeutic s
will target only one arm of the pathology and leave the retina open
to damaging consequences of the others. State-of-the-art,
comprehensive, and an invaluable addition the research and clinical
literature, Visual Dysfunction in Diabetes: The Science of Patient
Impairment and Improvement offers guidance and a significant step
toward new scientific approaches that can lessen the devastating
vision impairment associated with diabetes.
An exciting contribution to the field, Visual Dysfunction in
Diabetes: The Science of Patient Impairment and Improvement is
designed with two overriding objectives: to help readers understand
the impact of vision impairment in people living daily with
diabetes rather than considering diabetic retinopathy solely as a
medical problem, and to explore what we know and don't know about
the ways diabetes affect the eye. With the plethora of new
information being generated, there are still a series of
fundamental questions that must be addressed if effective
treatments for diabetic retinopathy are to be found and applied.
Developed by a renowned group of authorities, Visual Dysfunction in
Diabetes: The Science of Patient Impairment and Improvement offers
responses and context for a range of questions, such as: do
metabolic factors beyond glucose contribute to vision-threatening
diabetic retinopathy? If so, how do these lead to vision
impairment? Is diabetic retinopathy a response to systemic
metabolic abnormalities or are there unique ocular problems related
to insulin resistance? What is the relationship between the neural,
vascular, and inflammatory abnormalities in diabetic retinopathy?
Do they represent a pathological cascade induced sequentially or
simultaneous responses to one or more metabolic perturbations? The
authors note that if we do not address these types of questions, it
is possible that the long process of developing new therapeutic s
will target only one arm of the pathology and leave the retina open
to damaging consequences of the others. State-of-the-art,
comprehensive, and an invaluable addition the research and clinical
literature, Visual Dysfunction in Diabetes: The Science of Patient
Impairment and Improvement offers guidance and a significant step
toward new scientific approaches that can lessen the devastating
vision impairment associated with diabetes.
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