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This book comprehensively describes alkaptonuria and ochronosis.
Beginning with the history, genetics, pathophysiology and
diagnostics of the disease, the authors subsequently present a
detailed characterization of its clinical manifestation in the
spine, peripheral joints, eyes, ears, visceral organs and
respiratory tract, its pathological anatomy and histology, as well
as differential diagnosis. This is complemented by the latest data
on therapy and experimental models of alkaptonuria, and supported
by several case reports. Numerous pictures and radiological images
document the clinical symptoms, giving the reader a solid
understanding of the disease. On the basis of the editor's and
authors' own extensive observations, the book offers an analysis of
protein metabolism and aromatic amino acids in the context of
alkaptonuria. Written by international experts in the field, the
book offers a valuable reference guide for healthcare professionals
working in rheumatology, dermatology, pulmonology, otolaryngology
and histopathology.
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