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Intended for medical oncologists, surgeons, obstetricians,
gynecologists, geneticists, genetic counselors, and primary care
physicians, this text presents the epidemiological, biological, and
clinical issues associated with hereditary breast cancer. It offers
clear guidance on the application and utilization of cancer risk
assessment models, genetic counseling and testing of high risk
patients, and screening and prevention options for individuals at
risk of hereditary breast cancer. Addressing every essential aspect
of hereditary breast cancer, this
source offers comprehensive analyses of hereditary breast
cancer-associated syndromes, low penetrance genes, and hereditary
breast cancer associated with mutations in the BRCA1 and BRCA2
genes.
This volume comprises the investigation of factors that may predict
the response to treatment, outcome, and survival by exploring: *
design considerations in molecular epidemiology, including:
case-only family-based approaches for evaluation of genetic
susceptibility to exposure and addiction pharmacogenetics
incorporation of biomarkers in clinical trials * measurement issues
in molecular epidemiology, including DNA biosampling methods
principles for high-quality genotyping haplotypes biomarkers of
exposure and effect exposure assessment * methods of statistical
inference used in molecular epidemiology, including gene-gene and
gene-environment interaction analysis novel high-dimensional
analysis approaches pathway-based analysis methods haplotype
methods, dealing with race and ethnicity risk models a discussion
of reporting and interpreting results * A specific discussion and
synopsis of these methods provides concrete examples drawn from
primary research in cancer Covering design considerations,
measurement issues, and methods of statistical inference, and
filled with scientific tables, equations, and pictures, Molecular
Epidemiology: Applications in Cancer and Other Human Diseases
presents a solid, single-source foundation for conducting and
interpreting molecular epidemiological studies.
Intended for medical oncologists, surgeons, obstetricians,
gynecologists, geneticists, genetic counselors, and primary care
physicians, this text presents the epidemiological, biological, and
clinical issues associated with hereditary breast cancer. It offers
clear guidance on the application and utilization of cancer risk
assessment models, genetic counseling and testing of high risk
patients, and screening and prevention options for individuals at
risk of hereditary breast cancer. Addressing every essential aspect
of hereditary breast cancer, this source offers comprehensive
analyses of hereditary breast cancer-associated syndromes, low
penetrance genes, and hereditary breast cancer associated with
mutations in the BRCA1 and BRCA2 genes.
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