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Assuming little previous knowledge of biology, this book aids
graduate chemists to close the gap in their knowledge of
pharmacology and make the link between medicinal chemistry and the
way in which drugs act on the body. The availability of receptor
structures has revolutionized drug discovery and development
necessitating an up-to-date source of information for chemists
entering this new pharmacological world. Chapters, written by
experts with an appreciation of most graduate chemists' knowledge,
explain the history of pharmacology, the relationship between
receptor structure and function and receptor pharmacology relevant
to drug design. Importantly, as drugs are normally discovered in
test rather than therapeutic systems, this text describes how
pharmacology provides methods to characterize drug activity through
scales that allow prediction of drug effect in all systems.
Moreover, it outlines the relationship between drug distribution in
the body and the action of drugs in particular organ systems
relevant to disease. Readers will also find information on
pharmacokinetics and drug metabolism, safety pharmacology and
toxicology, clinical and regulatory pharmacology and the use of
imaging techniques. Carefully edited for relevance to the modern
chemist, this unique textbook will be an essential resource for
chemists planning to work in drug discovery, or postgraduate
students and practicing chemists interested in expanding their
pharmacology knowledge
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