Burkholderia are a multi-faceted group of bacteria with considerable genetic and metabolic diversity and very versatile lifestyles. In this book leading international investigators review key advances in Burkholderia research to provide timely overview. The topics covered include: genomic taxonomy and biodiversity, comparative genomics, molecular epidemiology, transcriptomics, proteomics, molecular pathogenesis of virulence in B. mallei/B. pseudomallei and the Burkholderia cepacia complex. The theme underpinning each chapter is the use of DNA/protein sequence data and post-genomic technologies to understand Burkholderia biology.

Members of the genus Burkholderia are a fascinating group of bacteria exhibiting immense ecological and metabolic diversity. Their notoriety as pathogens, including that of potential biological weapons, is ironically matched by their value as biopesticides and bioremediators. For example, B. cepacia complex organisms can reduce an onion bulb to a macerated pulp, protect other crops from bacterial and fungal disease, clean up aquifers and soils contaminated by recalcitrant herbicides, colonise the lungs of people with cystic fibrosis and, if this diversity is not striking enough, are not only innately resistant to most major groups of antibiotics, but can use that most famous of antimicrobials, penicillin G, as a nutrient This amazing versatility has attracted huge scientific interest in recent years and given that nine completed and seventeen draft Burkholderia genome sequences now available, the point has been reached where there is an urgent need to summarise and review the molecular biology, genomics, biochemistry, pathogenesis and beneficial properties of these important organisms. This volume brings together the expertise and enthusiasm of an international panel of leading Burkholderia researchers to provide a state-of-the art overview of these important organisms. Topics covered include epidemiology, comparative genomics, antibiotic resistance, polysaccharides, beneficial interaction with plants, and much more. Each chapter is independent and can be read in isolation, but as a whole the book provides an important resource summarising our current knowledge of Burkholderia molecular biology and genomics. It is an essential reading for all researchers working with Burkholderia and related organisms, and recommended reading for other scientists working bacterial genomics, antibacterial research, bacterial molecular and cellular biology, environmental microbiology, and bioremediation.