This book constitutes the thoroughly refereed post-proceedings of three workshops and an industrial track held in conjunction with the 11th Pacific-Asia Conference on Knowledge Discovery and Data Mining, PAKDD 2007, held in Nanjing, China in May 2007.

The 62 revised full papers presented together with an overview article to each workshop were carefully reviewed and selected from 355 submissions. The volume contains papers of the PAKDD 2007 industrial track, that promotes industry applications of new data mining techniques, methodologies and systems, the workshop on Data Mining for Biomedical Applications (BioDM 2007), the workshop on High Performance Data Mining and Applications (HPDMA 2007), as well as the workshop on on Service, Security and its Data management for Ubiquitous Computing (SSDU 2007).

The LNCS journal Transactions on Computational Systems Biology is devoted to inter- and multidisciplinary research in the fields of computer science and life sciences and supports a paradigmatic shift in the techniques from computer and information science to cope with the new challenges arising from the systems oriented point of view of biological phenomena.

This, the 5th Transactions on Computational Systems Biology volume, edited by Xiaohua Hu, Yi Pan and Tsau Young Lin, features a number of carefully selected and enhanced contributions initially presented at the 2005 IEEE International Conference on Granular Computing held in Beijing, China, in July 2005.

The 9 papers selected for this special issue are devoted to various aspects of computational methods, algorithms and techniques in bioinformatics such as gene expression analysis, biomedical literature mining and natural language processing, protein structure prediction, biological database management and biomedical information retrieval.