Off the coast of Mexico, Dr Susan McAlester's (Saffron Burrows) team of scientists are working on a cure for Alzheimer's disease by injecting degenerate human brain cells into mako sharks. The three sharks selected grow to over forty feet in length, and begin to demonstrate signs of intelligent behaviour. When pharmaceuticals' president Russell Franklin (Samuel L. Jackson) arrives with funding in mind, one of the sharks attacks scientist Jim Whitlock, biting off his arm. However, the helicopter taking Whitlock to surgery crashes into the research centre and disables the protective security systems which keeps the killer sharks at bay...

Off the coast of Mexico, Dr Susan McAlester's (Saffron Burrows) team of scientists are working on a cure for Alzheimer's disease by injecting degenerate human brain cells into mako sharks. The three sharks selected grow to over forty feet in length, and begin to demonstrate signs of intelligent behaviour. When pharmaceuticals' president Russell Franklin (Samuel L. Jackson) arrives with funding in mind, one of the sharks attacks scientist Jim Whitlock, biting off his arm. However, the helicopter taking Whitlock to surgery crashes into the research centre and disables the protective security systems which keeps the killer sharks at bay...

When the brothers Smuntz (Nathan Lane and Lee Evans) inherit a valuable mansion, they immediately try to sell up and take the money. Trouble is, no one will buy it until they get rid of the house's one remaining occupant, a stubborn and tenacious little mouse. The mouse, however, has other ideas for them.