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The understanding of chemokines, the proteins that control the
migration of cells, and their receptors, is critical to the study
of causes and therapies for a wide range of human diseases and
infections, including certain types of cancer, inflammatory
diseases, HIV, and malaria. This volume, focusing on chemokine
structure and function, as well as signaling, and its companion
volume ("Methods in Enzymology" volume 461, focusing on chemokines
as potential targets for disease intervention) provide a
comprehensive overview and time-tested protocols in this field,
making it an essential reference for researchers in the area.
The understanding of chemokines, the proteins that control the
migration of cells, and their receptors, is critical to the study
of causes and therapies for a wide range of human diseases and
infections, including certain types of cancer, inflammatory
diseases, HIV, and malaria. This volume, focusing on chemokines as
potential targets for disease intervention, and its companion
volume ("Methods in Enzymology" volume 462, focusing on chemokine
structure and function, as well as signaling) provide a
comprehensive overview and time-tested protocols in this field,
making it an essential reference for researchers in the area.
Chemokines, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in chemokines, and includes sections on such topics as chemokine detection using receptors, tracking cellular responses to chemokines, recognition of GAG-bound chemokines, and the production of chemokine receptor complexes for structural and biophysical studies.
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