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Overview and Goals This book describes how to visualize and compare
bacterial genomes. Sequencing technologies are becoming so
inexpensive that soon going for a cup of coffee will be more
expensive than sequencing a bacterial genome. Thus, there is a very
real and pressing need for high-throughput computational methods to
compare hundreds and thousands of bacterial genomes. It is a long
road from molecular biology to systems biology, and in a sense this
text can be thought of as a path bridging these ? elds. The goal of
this book is to p- vide a coherent set of tools and a
methodological framework for starting with raw DNA sequences and
producing fully annotated genome sequences, and then using these to
build up and test models about groups of interacting organisms
within an environment or ecological niche. Organization and
Features The text is divided into four main parts: Introduction,
Comparative Genomics, Transcriptomics and Proteomics, and ? nally
Microbial Communities. The ? rst ? ve chapters are introductions of
various sorts. Each of these chapters represents an introduction to
a speci? c scienti? c ? eld, to bring all readers up to the same
basic level before proceeding on to the methods of comparing
genomes. First, a brief overview of molecular biology and of the
concept of sequences as biological inf- mation are given.
Overview and Goals This book describes how to visualize and compare
bacterial genomes. Sequencing technologies are becoming so
inexpensive that soon going for a cup of coffee will be more
expensive than sequencing a bacterial genome. Thus, there is a very
real and pressing need for high-throughput computational methods to
compare hundreds and thousands of bacterial genomes. It is a long
road from molecular biology to systems biology, and in a sense this
text can be thought of as a path bridging these ? elds. The goal of
this book is to p- vide a coherent set of tools and a
methodological framework for starting with raw DNA sequences and
producing fully annotated genome sequences, and then using these to
build up and test models about groups of interacting organisms
within an environment or ecological niche. Organization and
Features The text is divided into four main parts: Introduction,
Comparative Genomics, Transcriptomics and Proteomics, and ? nally
Microbial Communities. The ? rst ? ve chapters are introductions of
various sorts. Each of these chapters represents an introduction to
a speci? c scienti? c ? eld, to bring all readers up to the same
basic level before proceeding on to the methods of comparing
genomes. First, a brief overview of molecular biology and of the
concept of sequences as biological inf- mation are given.
Sue Swanson, a self-employed scientific consultant living in
Germany, is frustrated with her life. For lack of work, she seeks
an occupation to keep herself busy, and applies for an unusual job
at a pharmaceutical company. When she discovers that some of the
medicines produced on site appear to be faulty, she looses the job,
but the director demands her services back in an even more unusual
manner. Not knowing whether she can trust him, she decides to
accept his request to investigate under cover. Soon, more
irregularities become apparent, and when the first victim presents
itself, Sue is determined to get to the bottom of it
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