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In this book the first three chapters outline the chemistry of
nickel and heme largely associated with anaerobic life and believed
to represent reactions which took place some 3-4x109years ago.
Nickel has disappeared from the chemistry of man. The fascinating
detail of the "primitive" catalysts is of interest to industrial
society since very simple feed-stock is used, hydrogen, carbon
monoxide and sulphate for example. The fourth chapter switches
attention to a metal which became valuable later in evolution,
copper, and which is involved with the use of dioxygen. It also has
extremely interesting catalytic sites in enzymes. The essence of
the volume lies in an appreciation of metallo- enzymes and their
changing roles as the environment changed.
l Tumor transformation produces numerous antigenic alterations ),
particularly 2 among the glycoconjugates, sugars linked to each
other, to lipids and to proteins , 3). Many blood group antigens
are identified as glycoconjugates; they include the 4 ABO(H) , MNT,
Lewis, Ii and P antigens ). These determinants are particularly
valuable since they can be understood in terms of their serology,
chemical structure and biochemical genetics4-7). Their specific
functions are not well understood; how ever, their position as
terminal or penultimate sugars may assign them a special role lO as
protective or informational moleculesS- ). Ordinarily, these
antigens, equally 4lO described on erythrocytes ), persist
unchanged throughout the lifetime of the indi vidual, but they may
be susceptible to alterations in the presence of certain
hematopoietic diseases and solid tissue tumors, primarily
carcinomas. A review of 11 this topic was published by one of us in
1980 ). New data has accumulated rapidly since then, particularly
in the areas of structural analysis, biochemical genetics, and
immunologic and tumor marker relationships. The purpose of this
review is to provide an update of progress realized in these areas.
Other reviews with emphasis 12 l5 on special areas are also
available - ). Current and prospective experimental studies should
be of use in regard to the following questions: 1.
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