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150 years after the first description of the clinical picture of
"white blood" and the introduction of the term "leukemia" by R.
Virchow it appears, that the leukemias, and the acute leukemias in
particular, serve as an impressive example for the major
improvements that have been achieved in the treatment but also in
the understand ing of the biology of malignant dis orders. The
international symposia "Acute Leukemia" which are held at Munster
since 1986 have developed into an interna tional forum to review
the current progress and the future perspectives of leukemia
research and therapy at a high scientific and clinicallevel. Since
the possibility for active participation in these symposia is
somewhat restricted we are glad to have the opportunity to extend
the information that was presented at the symposium "Acute
Leukemias V - Experimental Approaches and Management of Refractory
Disease" which was held from February 27 to March 2, 1994 to a
broader audience of basic scientists and clinicians. This meeting
was especiaIly designed to discuss experimen tal approaches and the
management of refractory disease which allows to evaluate new
experimental therapies on the basis of preclinical studies."
Since 1987 Acute Leukemias (AL) has regularly reported on the state
of the art in the rapidly growing, successful and exciting field of
biology and management of these diseases. In this volume large
multicenter clinical trials again form the solid basis for the
investigation of leukemic cell biology, the detection of biologic
subgroups, their differential response to alternative treatment
strategies and the further development of therapy. In particular,
this volume addresses mechanisms of chromosomal translocations and
transcription factors, risk-adapted treatment strategies,
differentiation therapy, secondary AL, special aspects in older
patients, and adoptive immunotherapy. Besides the antileukemic
approaches, supportive treatment with new antimicrobial substances
and growth factors is updated. As a forum of worldwide activities
in the field of AL this volume contains both exhaustive overviews
on major clinical issues and preliminary data and hypotheses not
previously published.
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